The Neuroradiological Spectra of Adult and Pediatric Medulloblastoma Differ

Beier, Dagmar; Kocakaya, Selin; Hau, Peter; Beier, Christoph P.

doi:10.1007/s00062-016-0517-0

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…In our study, the three most prevalent histological types of PFT were pilocytic astrocytomas (32.71%), medulloblastomas (33.17%), and anaplastic ependymomas (15.42%). These findings are consistent with previous studies, indicating that these types of tumors are the most commonly occurring in the posterior fossa [1,6,23,[26][27][28][29].The prevalence of other tumor types, such as atypical rhabdoid/teratoid tumors, hemangioblastomas, vestibular schwannoma, gangliocytomas of the cerebellum, and meningiomas, was relatively low, accounting for 18-19% of cases.…”

Section: Discussionsupporting

confidence: 92%

Clinicopathological Analysis of Pediatric Posterior Fossa Tumors: Insights from a National Neurosurgical Center

Mammadinova,

Seitbekov,

Surdin

et al. 2024

J CLIN MED KAZ

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BACKGROUNDː Pediatric posterior fossa tumors are the significant cause of morbidity and mortality in children and adolescents. This study aimed to investigate the characteristics of the patient population and report the experience in managing and treating children with these tumors, as well as their survival outcomes in Kazakhstan.<br /> METHODSː This retrospective study analysed data from the archives of the Pediatric Neurosurgery Department and included 214 pediatric patients with PFT in the period from January 2015 to December 2020.<br /> RESULTSː The study included 214 patients with a mean age of 7.29 ± 4.26 years. The most common tumor pathology observed in this study was medulloblastoma (33.18%). Grade I tumors showed a notable median survival of 56.64 months (95% CI, 53.93-59.35), surpassing Grade II tumors at 50.38 months (95% CI, 40.57-60.2). Grade III and IV tumors had median survivals of 38.64 months (95% CI, 31.11-46.17) and 38.76 months (95% CI, 33.96-43.56). Multivariate analysis using Cox regression model revealed significant predictors of overall survival. Grade III-IV tumors (RR = 0.577, 95% CI 0.462-0.720, p = 0.000), delayed resection (RR = 0.950, 95% CI 0.717-1.104, p = 0.000), and brainstem tumors (RR = 2.454, 95% CI 1.791-5.751, p = 0.000) had poorer survival. Tumor volume, age, and adjuvant chemotherapy were not significant predictors of 5-year survival (p > 0.05).<br /> CONCLUSIONSː The study found similar death rates in children with pilocytic astrocytoma compared to other population studies. Regrettably, the 5-year survival rate for medulloblastoma and ependymoma indicates a poorer outcome compared to previous reports.

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Section: Discussionsupporting

confidence: 92%

Clinicopathological Analysis of Pediatric Posterior Fossa Tumors: Insights from a National Neurosurgical Center

Mammadinova,

Seitbekov,

Surdin

et al. 2024

J CLIN MED KAZ

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“…7 – 9 In light of the recent discovery of molecular subgroups, this heterogeneity can now actually be seen as a normal reflection of significantly different tumour types, and may aid in the imaging diagnosis of medulloblastoma subtypes. 10 Our case report adds important features regarding these heterogeneous imaging aspects.…”

Section: Discussionmentioning

confidence: 72%

“…While SHH tumours have been shown to be laterally localized, WNT tumours are located more paramedially, which is concordant with our findings. 10 Other imaging findings have so far not been correlated with molecular subgroups, probably owing to the low prevalence of medulloblastoma in the adult population.…”

Section: Discussionmentioning

confidence: 99%

Adult-onset medulloblastoma presenting as slow-growing, atypical mass: a case report

Kolk

PoulsenLouise

2017

BJR|case reports

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Medulloblastoma accounts for < 1% of all primary central nervous system tumours in adults. Although a “classical” imaging presentation —being a well-defined mass, often located in the cerebellar hemisphere, with surrounding oedema, showing T1 iso- and T2 heterogeneous signal intensity and contrast enhancement —has been described, case reports and series have also shown the extremely heterogeneous imaging aspect of this tumour , reflecting its heterogeneous molecular phenotype. Owing to the general location of the tumour within the cerebellopontine angle, causing (fast) progressive symptoms of headache and gait instability, most patients present within 3 months from symptom onset. This case report describes a presentation of adult medulloblastoma not shown before, with an indolent course over a period of 4.5 years, initially without clear abnormalities on imaging. It highlights the importance of including medulloblastoma in the differential diagnosis of all lesions found near/continuous with the fourth ventricle in the adult population, even when clinical onset and imaging characteristics do not suggest “classical” medulloblastoma.

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“…However, Malheiros et al reported that most adult‐onset medulloblastomas occurred in the cerebellar hemisphere, were poorly defined, had slight and heterogeneous contrast enhancement, especially for a classic medulloblastoma, and had cystic appearances on T2‐weighted images 3 . Also, we collected and analyzed the papers about MRI findings of adult‐onset medulloblastoma, which realized that lateral asymmetrical location (76/125, 60.8%) 3‐6 and mass effect (24/26, 92.3%) 3,5,6 could be common characteristics compared to pediatric medulloblastoma in the limited reports. Our case fulfilled the common MRI characteristics of adult‐onset medulloblastoma but was atypical because the tumor was symmetrically located in the paramedian site with no mass effect.…”

Section: Discussionmentioning

confidence: 97%