The neuroscience and endocrinology of fibromyalgia

Pillemer, Stanley R.; Bradley, Laurence A.; Crofford, Leslie J.; Moldofsky, Harvey; Chrousos, George P.

doi:10.1002/art.1780401103

Cited by 199 publications

(105 citation statements)

References 58 publications

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“…8 Different hypotheses on the aetiology of fibromyalgia have been suggested. [9][10][11][12][13] It has also been argued that fibromyalgia is too heterogeneous a condition to consider only one single aetiology, and it has been questioned whether it is a disease entity or one end of a continuous spectrum of pain. [14][15][16] The result of this study indicates high prevalence of fibromyalgia about 40.7%.…”

Section: Discussionmentioning

confidence: 99%

Is fibromyalgia the most common diagnosis amongst female out-patients?

Jilumudi

Ram

2017

Int J Res Orthop

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Background: The objectives of this study were to determine the prevalence of fibromyalgia syndrome (FMS) among women coming to outpatient department.Methods: A total of 68,625 female patients were evaluated out of which 47,901 were in the inclusion criteria. The screening protocol included interview items that have been defined as components of FMS using the 1990 American College of Rheumatology (ACR) classification criteria. Data was entered in mx excel sheet and results were analyzed. The socio-demographic data was expressed in proportions.Results: Out of 47,901 female patients, about 40.7% of the patients were diagnosed to have fibromyalgia syndrome (FMS). Out of which the major group of patients belong to married, unskilled women aged between 40-60 years of age. Conclusions: Fibromyalgia syndrome is the commonest diagnosis among the female patients coming to orthopedic outpatient department.

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Section: Discussionmentioning

confidence: 99%

Is fibromyalgia the most common diagnosis amongst female out-patients?

Jilumudi

Ram

2017

Int J Res Orthop

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“…In a recent double-blind randomized study, Crofford et al [18] revealed the effectiveness of pregabalin (450 mg/day) in pain decrease as well as fatigue and sleep improvements as compared with a placebo group. Melatonin does not seem to improve the quality of sleep in FM patients, despite its regulatory action on the various cycles [62]. Ketamine, a molecule blocking the N-methyl-D-aspartate receptors, appears effective in decreasing pain perception [35].…”

Section: Therapy and Benefits Of Reconditioning Programsmentioning

confidence: 99%

Benefits of physical training in fibromyalgia and related syndromes

Maquet

Demoulin

Croisier

et al. 2007

Annales de Réadaptation et de Médecine Physique

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Objective. -To review the published information on physical training for fibromyalgia (FM) and related syndromes. Methods. -A search of Medline literature (via Ovid and PubMed) with the following keywords: FM, chronic fatigue syndrome, therapy, rehabilitation, aerobic, exercise, and cognitive behavioral therapy. The reference lists of articles were examined for additional related articles.Results. -Several studies investigated the benefits of graded exercise therapy for patients with FM or related syndromes. Although some systematic reviews have not established an unequivocal benefit of physical training, most authors report a benefit for patients with chronic pain or fatigue. Ideally, such a therapy should be a part of multidisciplinary program. Muscular rehabilitation is reserved for preventing the deconditioning syndrome often reported in patients and the vicious cycle of pain, avoidance and inactivity behaviors, or even kinesiophobia, deconditioning, incapacity and psychological distress.Conclusion. -This review emphasizes the relevance of graded physical training for treating FM and related syndromes. The development of rehabilitation centers, with experts able to propose a relevant therapy to patients with chronic pain or fatigue, should help alleviate this public health problem.

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“…3 Although its pathogenesis has not been totally clarifi ed, several authors consider it either a disorder of the central modulation of pain or an altered central nervous system processing in response to a nociceptive stimulus. [4][5][6][7][8] Recent evidence has suggested the participation of environmental factors acting on genetically predisposed individuals developing these disease. 9 The investigation on the involvement of autonomic nervous system and hypothalamuspituitary-adrenal axis has also suggested that these systems of response to stress play a role in fi bromyalgia susceptibility or in the expression of its symptoms.…”

Section: Introductionmentioning

confidence: 99%

Uso da terapia não farmacológica, medicina alternativa e complementar na fibromialgia

Braz¹,

Paula

Diniz³

et al. 2011

Rev. Bras. Reumatol.

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Fibromyalgia is a chronic painful syndrome that affects up to 5% of the world population. It is associated with sleep and mood disorders, fatigue, and functional disability. Its pathogenesis involves a disorder of the central modulation of pain, impairment of the descending inhibitory system, and hyperactivity of substance P. Because of the extensive symptomatology of patients with fi bromyalgia and its multifactorial pathogenesis, its ideal treatment requires a multidisciplinary approach including the association of pharmacological and non-pharmacological therapies. The pharmacological therapy currently recommended for the syndrome includes antidepressants, calcium-channel modulators, muscle relaxants, and analgesics. In most cases, the non-pharmacological treatment consists of patient education, supervised aerobic physical activity, and cognitive-behavioral therapy. However, many patients do not respond satisfactorily, or have side effects associated with the long-term use of drugs, in addition to reporting diffi culties in adhering to a therapy based on exercises and physical medicine. Thus, physicians and patients are increasingly interested in an alternative and complementary therapy for fi bromyalgia. This review approaches the different therapeutic modalities used in fi bromyalgia, emphasizing the evidence of non-pharmacological therapy and use of alternative and complementary medicine for these patients.

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The neuroscience and endocrinology of fibromyalgia

Cited by 199 publications

References 58 publications

Is fibromyalgia the most common diagnosis amongst female out-patients?

Is fibromyalgia the most common diagnosis amongst female out-patients?

Benefits of physical training in fibromyalgia and related syndromes

Uso da terapia não farmacológica, medicina alternativa e complementar na fibromialgia

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