The neurotoxicity of environmental aluminum is still an issue

Bondy, Stephen Bondy C

doi:10.1016/j.neuro.2010.05.009

Cited by 274 publications

(163 citation statements)

References 78 publications

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“…In mammals, Al accumulation in the brain has been suggested to be involved in the development of neurodegenerative disorders, amyotrophic lateral sclerosis, and dialysis encephalopathy (Flora et al 2003;Bondy 2010). Similar changes in brain have been found in rainbow trout exposed to Al (Exley et al 1997).…”

mentioning

confidence: 66%

Fish kill caused by aluminium and iron contamination in a natural pond used for fish rearing: a case report

Slaninova¹,

Máchová²,

Svobodová³

2014

Vet. Med.

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ABSTRACT:Contamination of Pansky Pond, in March 2013, with 119 mg/l aluminium, and 87 mg/l iron by acidic (pH 3.17) inflow from a nearby quarry caused fish die-off, while exhibiting symptoms of suffocation. Transformation of soluble forms of aluminium and iron into insoluble forms occurred on fish gill where the content of aluminium and iron was 100-fold and 12-fold, respectively, that found in control fish in an unaffected pond. In addition to insoluble aluminium and iron, gills showed presence of iron bacteria. Histopathology was characterised by expression of reactive processes and regressive alterations resulting in gill tissue necrosis. Impairment of the excretory function of gills was reflected in significantly (P < 0.01) higher concentrations of ammonia in the blood plasma of exposed fish compared to the control. Damage to parenchymatous tissues (kidney, liver, spleen) of the exposed fish was manifested as dystrophic alterations, higher aluminium and iron content, and enhanced activity of transaminases in blood plasma compared to the control.

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mentioning

confidence: 66%

Fish kill caused by aluminium and iron contamination in a natural pond used for fish rearing: a case report

Slaninova¹,

Máchová²,

Svobodová³

2014

Vet. Med.

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show abstract

“…This chronic state of inflammation can be a self-promoting process may play an important role in advancing neurodegeneration Lucin and Wyss-Coray, 2009). Many age-related neurological diseases involve the appearance of an even higher level of inflammation than that found in normal brain aging (Bondy, 2010).…”

Section: Inflammation Is Pronounced In the Aging Brain And This Is Fmentioning

confidence: 99%

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

Bondy

2016

NeuroToxicology

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208

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“…The neurotoxicity of aluminium has been demonstrated in humans, animal models and in tissue and cell culture [1]. While aluminium's neurotoxicity is incontrovertible, it is much more difficult to understand the risk that this neurotoxin poses to human health.…”

Section: Aluminium the Neurotoxinmentioning

confidence: 99%

What is the risk of aluminium as a neurotoxin?

Exley

2014

Expert Review of Neurotherapeutics

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The neurotoxicity of environmental aluminum is still an issue

Cited by 274 publications

References 78 publications

Fish kill caused by aluminium and iron contamination in a natural pond used for fish rearing: a case report

Fish kill caused by aluminium and iron contamination in a natural pond used for fish rearing: a case report

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

What is the risk of aluminium as a neurotoxin?

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