The neurotoxicity of trichothecenes T-2 toxin and deoxynivalenol (DON): Current status and future perspectives

Zhang, Jiajia; Li, You; Wu, Weijie; Wang, Xu; Chrienová, Žofia; Nepovimová, Eugenie; Wu, Qinghua; Kuča, Kamil

doi:10.1016/j.fct.2020.111676

Cited by 56 publications

(27 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Trichothecenes are chemically defined as sesquiterpene epoxides, able to cause toxicoses in humans or non-human animals that consume contaminated food or feed [9,10]. These compounds may inhibit eukaryotic protein synthesis [11], induce apoptosis [12,13] and may play a key role as virulence factors [14,15].…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking and Comparative Inhibitory Efficacy of Naturally Occurring Compounds on Vegetative Growth and Deoxynivalenol Biosynthesis in Fusarium culmorum

Oufensou

Dessì

Dallocchio

et al. 2021

Toxins

View full text Add to dashboard Cite

The fungal pathogen Fusarium culmorum causes Fusarium head blight in cereals, resulting in yield loss and contamination of the grain by type B trichothecene mycotoxins such as deoxynivalenol (DON), and its acetylated derivatives. Synthesis of trichothecenes is driven by a trichodiene synthase (TRI5) that converts farnesyl pyrophosphate (FPP) to trichodiene. In this work, 15 naturally occurring compounds that belong to the structural phenol and hydroxylated biphenyl classes were tested in vitro and in planta (durum wheat) to determine their inhibitory activity towards TRI5. In vitro analysis highlighted the fungicidal effect of these compounds when applied at 0.25 mM. Greenhouse assays showed a strong inhibitory activity of octyl gallate 5, honokiol 13 and the combination propyl gallate 4 + thymol 7 on trichothecene biosynthesis. Docking analyses were run on the 3D model of F. culmorum TRI5 containing the inorganic pyrophosphate (PPi) or FPP. Significant ligand affinities with TRI-PPi and TRI-FPP were observed for the same sites for almost all compounds, with 1 and 2 as privileged sites. Octyl gallate 5 and honokiol 13 interacted almost exclusively with sites 1 and 2, by concurrently activating strong H-bonds with common sets of amino acids. These results open new perspectives for the targeted search of naturally occurring compounds that may find practical application in the eco-friendly control of FHB in wheat.

show abstract

Section: Introductionmentioning

confidence: 99%

Molecular Docking and Comparative Inhibitory Efficacy of Naturally Occurring Compounds on Vegetative Growth and Deoxynivalenol Biosynthesis in Fusarium culmorum

Oufensou

Dessì

Dallocchio

et al. 2021

Toxins

View full text Add to dashboard Cite

show abstract

“…The activation of Nrf2/HO-1 was postulated as a main response element in other cells exposed to DON e.g. DON-induced neurotoxicity (Zhang et al 2020) or generally one of the basic cell signaling element in the response to mycotoxins (Kozieł et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Deoxynivalenol induces apoptosis and autophagy in human prostate epithelial cells via PI3K/Akt signaling pathway

et al. 2021

View full text Add to dashboard Cite

Phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway is one of the most deregulated signaling pathway in prostate cancer. It controls basic processes in cells: cell proliferation and death. Any disturbances in the balance between cell death and survival might result in carcinogenesis. Deoxynivalenol (DON) is one of the most common mycotoxins, a toxic metabolites of fungi, present in our everyday diet and feed. Although previous studies reported DON to induce oxidative stress, modulate steroidogenesis, DNA damage and cell cycle modulation triggering together its toxicity, its effect on normal prostate epithelial cells is not known. The aim of the study was to evaluate the effect of DON on the apoptosis and autophagy in normal prostate epithelial cells via modulation of PI3K/Akt signaling pathway. The results showed that DON in a dose of 30 µM and 10 µM induces oxidative stress, DNA damage and cell cycle arrest in G2/M cell cycle phase. The higher concentration of DON induces apoptosis, whereas lower one autophagy in PNT1A cells, indicating that modulation of PI3K/Akt by DON results in the induction of autophagy triggering apoptosis in normal prostate epithelial cells.

show abstract

“…TCT are easily absorbed through the gastrointestinal membranes and distributed to different tissues and organs due to their low molecular weight and amphipathic nature. The consumption of TCT contaminated products may cause variable adverse effects including emesis, anorexia, carcinogenicity, hematotoxicity, immunotoxicity, and neurotoxicity [23][24][25][26]. Moreover, it has been reported that T-2 is extremely toxic to the mucous membranes and skin [27].…”

Section: Introductionmentioning

confidence: 99%

T-2 Toxin—The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies

et al. 2021

View full text Add to dashboard Cite

Among trichothecenes, T-2 toxin is the most toxic fungal secondary metabolite produced by different Fusarium species. Moreover, T-2 is the most common cause of poisoning that results from the consumption of contaminated cereal-based food and feed reported among humans and animals. The food and feed most contaminated with T-2 toxin is made from wheat, barley, rye, oats, and maize. After exposition or ingestion, T-2 is immediately absorbed from the alimentary tract or through the respiratory mucosal membranes and transported to the liver as a primary organ responsible for toxin's metabolism. Depending on the age, way of exposure, and dosage, intoxication manifests by vomiting, feed refusal, stomach necrosis, and skin irritation, which is rarely observed in case of mycotoxins intoxication. In order to eliminate T-2 toxin, various decontamination techniques have been found to mitigate the concentration of T-2 toxin in agricultural commodities. However, it is believed that 100% degradation of this toxin could be not possible. In this review, T-2 toxin toxicity, metabolism, and decontamination strategies are presented and discussed.

show abstract

The neurotoxicity of trichothecenes T-2 toxin and deoxynivalenol (DON): Current status and future perspectives

Cited by 56 publications

References 65 publications

Molecular Docking and Comparative Inhibitory Efficacy of Naturally Occurring Compounds on Vegetative Growth and Deoxynivalenol Biosynthesis in Fusarium culmorum

Molecular Docking and Comparative Inhibitory Efficacy of Naturally Occurring Compounds on Vegetative Growth and Deoxynivalenol Biosynthesis in Fusarium culmorum

Deoxynivalenol induces apoptosis and autophagy in human prostate epithelial cells via PI3K/Akt signaling pathway

T-2 Toxin—The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies

Contact Info

Product

Resources

About