1993
DOI: 10.1523/jneurosci.13-07-02739.1993
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The neurotrophic factor concept: a reexamination

Abstract: The neurotrophic factor concept in its basic form envisages that innervated tissues produce a signal for the innervating neurons for the selective limitation of neuronal death occurring during development (Purves, 1986; Oppenheim, 1991). This concept arose several decades ago on the basis of the observation that experimental manipulation of the amount of target tissue could modulate the size of neuronal populations. By making the survival of neurons dependent on their target, nature would provide a means to ma… Show more

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Cited by 710 publications
(364 citation statements)
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“…Neurotrophins include NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5, each of which binds to specific high-affinity receptors, the Trk family of receptors. Neurotrophins are particularly relevant to our studies of SG cell survival in neonatally-deafened animals because they regulate neuronal differentiation and survival during development (Korsching, 1993;Gao et al, 1995;Farinas et al, 2001;Fritzsch et al, 1999;Rubel and Fritsch, 2002) and are also involved in the development and maturation of the central auditory system (for review, see Fritzsch et al, 1999;Rubel and Fritzsch, 2002). Within the developing cochlea, neurotrophins are differentially distributed, with NT-3 expressed predominantly in the supporting cells of the organ of Corti, and BDNF expressed only in hair cells (Farinas, et al, 2001).…”
Section: The Role Of Neurotrophins In Survival Of Sg Neurons After Nementioning
confidence: 99%
“…Neurotrophins include NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5, each of which binds to specific high-affinity receptors, the Trk family of receptors. Neurotrophins are particularly relevant to our studies of SG cell survival in neonatally-deafened animals because they regulate neuronal differentiation and survival during development (Korsching, 1993;Gao et al, 1995;Farinas et al, 2001;Fritzsch et al, 1999;Rubel and Fritsch, 2002) and are also involved in the development and maturation of the central auditory system (for review, see Fritzsch et al, 1999;Rubel and Fritzsch, 2002). Within the developing cochlea, neurotrophins are differentially distributed, with NT-3 expressed predominantly in the supporting cells of the organ of Corti, and BDNF expressed only in hair cells (Farinas, et al, 2001).…”
Section: The Role Of Neurotrophins In Survival Of Sg Neurons After Nementioning
confidence: 99%
“…Both the neurotrophins and their receptors are expressed in the developing and adult CNS, and each of the neurotrophins has been shown to support survival and/or differentiation of CNS neurons in cell culture (for review, see Korsching, 1993). Despite this, comparatively few deficits have been seen in the brains of mice lacking individual neurotrophins or Trk receptors (for review, see Reichardt and Fariñas, 1997).…”
Section: Abstract: Trkb; Conditional Mutant; Ca1; Long-term Potentiamentioning
confidence: 99%
“…Because neurotrophins regulate neuronal differentiation and survival during development (Fariñas et al 2001;Fritzsch et al 1999;Gao et al 1995;Korsching 1993;Rubel and Fritzsch 2002;Tessarollo et al 2004;Yang et al 2011), we hypothesized that exogenous NTs might be particularly effective in our developing animals, after early-onset hearing loss. In our initial study, cats were deafened as neonates, implanted unilaterally and received 10 weeks of intracochlear BDNF starting at 4 weeks of age.…”
Section: Introductionmentioning
confidence: 99%