The neurovascular basis of processing speed differences in humans: A model-systems approach using multiple sclerosis

Sivakolundu, Dinesh K.; West, Kathryn L.; Zuppichini, Mark D.; Turner, Monroe P.; Abdelkarim, Dema; Zhao, Yuguang; Spence, Jeffrey S.; Lu, Hanzhang; Okuda, Darin T.

doi:10.1016/j.neuroimage.2020.116812

Cited by 10 publications

(12 citation statements)

References 82 publications

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“…Previous studies indicated a close association between aging and the breakdown of the BBB, suggesting that impairment of neurovascular coupling is responsible for the cognitive decline seen in the elderly (Fabiani et al, 2014;Balbi et al, 2015) and during neurodegenerative diseases such as AD (Fabiani et al, 2014;Tarantini et al, 2017) and MS (Sivakolundu et al, 2020).…”

Section: Neurovascular Coupling and The Bbbmentioning

confidence: 99%

Neuromodulation of Glial Function During Neurodegeneration

Stevenson

Samokhina

Rossetti

et al. 2020

Front. Cell. Neurosci.

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Glia, a non-excitable cell type once considered merely as the connective tissue between neurons, is nowadays acknowledged for its essential contribution to multiple physiological processes including learning, memory formation, excitability, synaptic plasticity, ion homeostasis, and energy metabolism. Moreover, as glia are key players in the brain immune system and provide structural and nutritional support for neurons, they are intimately involved in multiple neurological disorders. Recent advances have demonstrated that glial cells, specifically microglia and astroglia, are involved in several neurodegenerative diseases including Amyotrophic lateral sclerosis (ALS), Epilepsy, Parkinson's disease (PD), Alzheimer's disease (AD), and frontotemporal dementia (FTD). While there is compelling evidence for glial modulation of synaptic formation and regulation that affect neuronal signal processing and activity, in this manuscript we will review recent findings on neuronal activity that affect glial function, specifically during neurodegenerative disorders. We will discuss the nature of each glial malfunction, its specificity to each disorder, overall contribution to the disease progression and assess its potential as a future therapeutic target.

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Section: Neurovascular Coupling and The Bbbmentioning

confidence: 99%

Neuromodulation of Glial Function During Neurodegeneration

Stevenson

Samokhina

Rossetti

et al. 2020

Front. Cell. Neurosci.

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“…Studies examining NVC demonstrate mixed and contradictory results. Three studies, Stickland et al ( 96 ), Sivakolundu et al ( 74 ) and Hubbard et al ( 94 ) measured the change in CBF from neuronal activation (ΔCBF) in the visual cortex using the ASL MRI technique. Furthermore, Hubbard et al ( 94 ) and Sivakolundu et al ( 74 ) additionally calculated the change in CMRO 2 (ΔCMRO 2 ) using a calibrated BOLD technique to examine the coupling between CBF and CMRO 2 as a marker for NVC.…”

Section: Discussionmentioning

confidence: 99%

“…Three studies, Stickland et al ( 96 ), Sivakolundu et al ( 74 ) and Hubbard et al ( 94 ) measured the change in CBF from neuronal activation (ΔCBF) in the visual cortex using the ASL MRI technique. Furthermore, Hubbard et al ( 94 ) and Sivakolundu et al ( 74 ) additionally calculated the change in CMRO 2 (ΔCMRO 2 ) using a calibrated BOLD technique to examine the coupling between CBF and CMRO 2 as a marker for NVC. Stickland et al ( 96 ) acquired brain electrical activity using MEG to examine the NVC as the coupling between CBF and MEG gamma band power.…”

Section: Discussionmentioning

confidence: 99%

“…Given that the artery supplies not only the activated region but also other areas of the brain, the measured change in blood velocity is a diluted average of a much larger brain area. When measuring CBF by TCD, the response to visual stimulation results in an increase in the blood velocity through the PCA by ~5–40% and through the MCA by ~0–10% ( 71 – 73 ), in contrast to the much larger focal increase in perfusion in the visual cortex, which is ~50-100% ( 64 , 66 , 68 , 74 ). Thus, the examination of the CBF response by TCD is not fully quantifiable.…”

Section: Introductionmentioning

confidence: 99%

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Cerebrovascular Reactivity and Neurovascular Coupling in Multiple Sclerosis—A Systematic Review

et al. 2022

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The inflammatory processes observed in the central nervous system in multiple sclerosis (MS) could damage the endothelium of the cerebral vessels and lead to a dysfunctional regulation of vessel tonus and recruitment, potentially impairing cerebrovascular reactivity (CVR) and neurovascular coupling (NVC). Impaired CVR or NVC correlates with declining brain health and potentially plays a causal role in the development of neurodegenerative disease. Therefore, we examined studies on CVR or NVC in MS patients to evaluate the evidence for impaired cerebrovascular function as a contributing disease mechanism in MS. Twenty-three studies were included (12 examined CVR and 11 examined NVC). Six studies found no difference in CVR response between MS patients and healthy controls. Five studies observed reduced CVR in patients. This discrepancy can be because CVR is mainly affected after a long disease duration and therefore is not observed in all patients. All studies used CO2 as a vasodilating stimulus. The studies on NVC demonstrated diverse results; hence a conclusion that describes all the published observations is difficult to find. Future studies using quantitative techniques and larger study samples are needed to elucidate the discrepancies in the reported results.

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“…Moreover, arterial compliance seems to be reduced in MS patients with cognitive impairment [41]. The same group [42] showed a rela-…”

Section: Ta B L E 2 Comparison Of Cbf Valuesmentioning

confidence: 94%

Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function

Testud

Delacour

Ahmadi

et al. 2022

Euro J of Neurology

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Background and purpose Extent and dynamic of neurodegeneration in progressive multiple sclerosis (MS) might be reflected by global and regional brain perfusion, an outcome at the intercept between structure and function. Here, we provide a first insight into the evolution of brain perfusion and its association with disability in primary progressive MS (PPMS) over several years. Methods Seventy‐seven persons with PPMS were followed over up to 5 years. Visits included a 3‐T magnetic resonance imaging with pulsed arterial spin labelling perfusion, the Timed 25‐Foot Walk, 9‐Hole Peg Test (NHPT), Symbol Digit Modalities Test (SDMT), and Expanded Disability Status Scale (EDSS). We extracted regional cerebral blood flow surrogates and compared them to 11 controls. Analyses focused on cortical and deep grey matter, the change over time, and associations with disability on the regional and global levels. Results Baseline brain perfusion of patients and controls was comparable for the cortex (p = 0.716) and deep grey matter (p = 0.095). EDSS disability increased mildly (p = 0.023), whereas brain perfusion decreased during follow‐up (p < 0.001) and with disease duration (p = 0.009). Lower global perfusion correlated with higher disability as indicated by EDSS, NHPT, and Timed 25‐Foot Walk (p < 0.001). The motor task NHPT showed associations with 20 grey matter regions. In contrast, better SDMT performance correlated with lower perfusion (p < 0.001) in seven predominantly frontal regions, indicating a functional maladaptation. Conclusions Decreasing perfusion indicates a putative association with MS disease mechanisms such as neurodegeneration, reduced metabolism, and loss of resilience. A low alteration rate limits its use in clinical practice, but regional association patterns might provide a snapshot of adaptive and maladaptive functional reorganization.

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The neurovascular basis of processing speed differences in humans: A model-systems approach using multiple sclerosis

Cited by 10 publications

References 82 publications

Neuromodulation of Glial Function During Neurodegeneration

Neuromodulation of Glial Function During Neurodegeneration

Cerebrovascular Reactivity and Neurovascular Coupling in Multiple Sclerosis—A Systematic Review

Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function

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