The neurovascular unit in healthy and injured spinal cord

Zhou, Rubing; Li, Junzhao; Wang, Ruideng; Chen, Zhengyang; Zhou, Fang

doi:10.1177/0271678x231172008

“…Therefore, we plan to apply FSZ NPs in the local treatment of acute SCI with surgery to simulate the real clinical application scenario. However, a problem to be faced is that as SCI destroys the blood-spinal barrier, large amounts of cerebrospinal fluid and blood escape may lead to dilution and escape of nanomaterials, reducing therapeutic effectiveness [ 40 ]. Therefore, we selected GelMA hydrogel, a biological scaffold material with high biocompatibility, to immobilize FSZ NPs locally in SCI injury to overcome the above problems [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform

Zhou,

Li,

Jing

et al. 2024

J Nanobiotechnol

2

0

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Spinal cord injury (SCI) often results in motor and sensory deficits, or even paralysis. Due to the role of the cascade reaction, the effect of excessive reactive oxygen species (ROS) in the early and middle stages of SCI severely damage neurons, and most antioxidants cannot consistently eliminate ROS at non-toxic doses, which leads to a huge compromise in antioxidant treatment of SCI. Selenium nanoparticles (SeNPs) have excellent ROS scavenging bioactivity, but the toxicity control problem limits the therapeutic window. Here, we propose a synergistic therapeutic strategy of SeNPs encapsulated by ZIF-8 (SeNPs@ZIF-8) to obtain synergistic ROS scavenging activity. Three different spatial structures of SeNPs@ZIF-8 were synthesized and coated with ferrostatin-1, a ferroptosis inhibitor (FSZ NPs), to achieve enhanced anti-oxidant and anti-ferroptosis activity without toxicity. FSZ NPs promoted the maintenance of mitochondrial homeostasis, thereby regulating the expression of inflammatory factors and promoting the polarization of macrophages into M2 phenotype. In addition, the FSZ NPs presented strong abilities to promote neuronal maturation and axon growth through activating the WNT4-dependent pathways, while prevented glial scar formation. The current study demonstrates the powerful and versatile bioactive functions of FSZ NPs for SCI treatment and offers inspiration for other neural injury diseases.

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“…Simultaneously, there is a concerted effort to promote functional recovery, enhancing the overall quality of life for patients. Lastly, there is a continuous search for suitable grafts that could support and guide the process of axon regeneration, ensuring optimal outcomes, miRNA-based therapy, blood vessel intervention and combination of multiple treatments will play a key role in the treatment of SCI in the future ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Research hotspots and trends of microRNAs in spinal cord injury: a comprehensive bibliometric analysis

Hu,

Zhao,

Chen

et al. 2024

Front. Neurol.

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BackgroundSpinal cord injury (SCI) is a nervous system disease leading to motor and sensory dysfunction below the injury level, and can result in paralysis. MicroRNAs (miRNAs) play a key role in SCI treatment, and related research provides insights for SCI diagnosis and treatment. Bibliometrics is an important tool for literature statistics and evaluation, objectively summarizing multidimensional information. This study comprehensively overviews the field through bibliometric analysis of miRNA and SCI research, providing contemporary resources for future collaboration and clinical treatment.Materials and methodsIn this study, we searched the Web of Science Core Collection (WOSCC) database. After careful screening and data import, we extracted annual publications, citation counts, countries, institutions, authors, journals, highly cited articles, co-cited articles, keywords, and H-index. Bibliometrics and visualization analyses employed VOSviewer, CiteSpace, the R package “bibliometrix,” and online analytic platforms. Using Arrowsmith,1 we determined miRNA-SCI relationships and discussed potential miRNA mechanisms in SCI.ResultsFrom 2008 to 2024, the number of related papers increased annually, reaching 754. The number of yearly publications remained high and entered a period of rapid development. Researchers from 50 countries/regions, 802 institutions, 278 journals, and 3,867 authors participated in the field. Currently, China has advantages in the number of national papers, citations, institutions, and authors. However, it is necessary to strengthen cooperation among different authors, institutions, and countries to promote the production of important academic achievements. The research in the field currently focuses on nerve injury, apoptosis, and gene expression. Future research directions mainly involve molecular mechanisms, clinical trials, exosomes, and inflammatory reactions.ConclusionOverall, this study comprehensively analyzes the research status and frontier of miRNAs in SCI. A systematic summary provides a complete and intuitive understanding of the relationship between SCI and miRNAs. The presented findings establish a basis for future research and clinical application in this field.

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“…Therefore, we plan to apply FSZ NPs in the local treatment of acute SCI with surgery to simulate the real clinical application scenario. However, a problem to be faced is that as SCI destroys the blood-spinal barrier, large amounts of cerebrospinal uid and blood escape may lead to dilution and escape of nanomaterials, reducing therapeutic effectiveness [37]. Therefore, we selected GelMA hydrogel, a biological scaffold material with high biocompatibility, to immobilize FSZ NPs locally in SCI injury to overcome the above problems [38].…”

Section: Fsz Nps Promotes Neurite Outgrowth and Neuronal Maturationmentioning

confidence: 99%

Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform

Zhou,

Li,

Jing

et al. 2024

Preprint

0

View full text Add to dashboard Cite

Spinal cord injury (SCI) often results in motor and sensory deficits, or even paralysis. Due to the role of the cascade reaction, the effect of excessive reactive oxygen species (ROS) in the early and middle stages of SCI severely damage neurons, and most antioxidants cannot consistently eliminate ROS at non-toxic doses, which leads to a huge compromise in antioxidant treatment of SCI. Selenium nanoparticles (SeNPs) have excellent ROS scavenging bioactivity, but the toxicity control problem limits the therapeutic window. Here, we propose a synergistic therapeutic strategy of SeNPs encapsulated by ZIF-8 (SeNPs@ZIF-8) to obtain synergistic ROS scavenging activity. Three different spatial structures of SeNPs@ZIF-8 were synthesized and coated with ferrostatin-1, a ferroptosis inhibitor (FSZ NPs), to achieve enhanced anti-oxidant and anti-ferroptosis activity without toxicity. FSZ NPs promoted the maintenance of mitochondrial homeostasis, thereby regulating the expression of inflammatory factors and promoting the polarization of macrophages into M2 phenotype. In addition, the FSZ NPs presented strong abilities to promote neuronal maturation and axon growth through activating the WNT4-dependent pathways, while prevented glial scar formation. The current study demonstrates the powerful and versatile bioactive functions of FSZ NPs for SCI treatment and offers inspiration for other neural injury diseases.

show abstract

The neurovascular unit in healthy and injured spinal cord

Cited by 10 publications

References 181 publications

Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform

Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform

Research hotspots and trends of microRNAs in spinal cord injury: a comprehensive bibliometric analysis

Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform

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