2018
DOI: 10.1128/jvi.02074-17
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The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity

Abstract: Human herpesvirus 6A (HHV-6A) glycoprotein B (gB) is a glycoprotein consisting of 830 amino acids and is essential for the growth of the virus. Previously, we reported that a neutralizing monoclonal antibody (MAb) called 87-y-13 specifically reacts with HHV-6A gB, and we identified its epitope residue at asparagine (Asn) 347 on gB. In this study, we examined whether the epitope recognized by the neutralizing MAb is essential for HHV-6A infection. We constructed HHV-6A bacterial artificial chromosome (BAC) geno… Show more

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Cited by 3 publications
(3 citation statements)
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“…The entry of herpesvirus into host cells is usually described as a cascade (13). For HHV-6B, according to our results, the binding of the gH/gL/gQ1/gQ2 complex to its cell receptor, CD134, may activate glycoprotein B (gB) function (15,17). The conserved fusogens of herpesvirus, gB and gH, collaborate in mediating the fusion between the viral envelope and the cell membrane in the entry process (17).…”
Section: Discussionmentioning
confidence: 58%
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“…The entry of herpesvirus into host cells is usually described as a cascade (13). For HHV-6B, according to our results, the binding of the gH/gL/gQ1/gQ2 complex to its cell receptor, CD134, may activate glycoprotein B (gB) function (15,17). The conserved fusogens of herpesvirus, gB and gH, collaborate in mediating the fusion between the viral envelope and the cell membrane in the entry process (17).…”
Section: Discussionmentioning
confidence: 58%
“…For HHV-6B, according to our results, the binding of the gH/gL/gQ1/gQ2 complex to its cell receptor, CD134, may activate glycoprotein B (gB) function (15,17). The conserved fusogens of herpesvirus, gB and gH, collaborate in mediating the fusion between the viral envelope and the cell membrane in the entry process (17). The different binding domains of each MAb may exert different effects at each step of viral entry.…”
Section: Discussionmentioning
confidence: 84%
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