The Neutrophil Extracellular Traps: The Missed Link between Microvascular Inflammation and Diabetes?

Berezin, Alexander E.

doi:10.4172/2153-0769.1000163

Metabolomics

2016

DOI: 10.4172/2153-0769.1000163

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The Neutrophil Extracellular Traps: The Missed Link between Microvascular Inflammation and Diabetes?

Alexander E. Berezin¹

Abstract: Microvascular inflammation is considered as a trigger for vasculopathy and early atherosclerosis development in diabetes mellitus. However, activated mononuclears/macrophages/neutrophils play a pivotal role in pathogenesis of vascular complications among individuals with diabetes mellitus. The neutrophil extracellular traps (NETs) have been known as a component of innate immune system for the last few decades. NETosis is induced by pathogens as well as other stimuli such as activated platelets, metabolic trigg… Show more

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Cited by 2 publications

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COVID-19. Understanding of the consequences

Петюніна¹

2021

УТЖ

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The new coronavirus infection known as SARS‑CoV‑2 and firstly registered in Wuhan, China in late 2019, resulted in the severe crisis and a great number of lethal outcomes worldwide. Processes occurring in a body with virus infecting are quite polymorphic and involve all organs and systems. The first step in the infection is the virus binding with the host cell via target ACE‑2 receptors with resulting virus‑inducted down‑regulation of these receptors which, through a number of signaling pathways, leads to COVID‑related damage to an organ or system. Since ACE‑2 receptors play a leading role as an entrance gate for the virus, understanding of an axis of ACE/angiotensin receptor and ACE‑2/MAS‑receptor has the crucial significance in the investigation of infection role. The article presents review of the data from patients with delayed recovery after COVID‑19. The prolonged disease duration and disability are often inherent to the patients, hospitalized due to severe and critically severe disease forms. There is no universally accepted definition of «Long Covid», or post‑covid syndrome, but for convenience it was conditionally distinguished a subacute condition that lasts more than 3 weeks from the onset of the disease, and a chronic condition that lasts more than 12 weeks. Among the pathogenetic peculiarities, the activation of renin‑angiotensin‑aldosterone system, cytokine system, anti/prooxidant stress, coagulopathy, endothelial disfunction have been examined. Better understanding of the mechanisms that are realized at COVID‑19, will enable the rational use of the medicines for the disease treatment on all stages that may possibly prevent complications and prolonged consequences of the infection as well as improve the quality of life of patients.

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COVID-19. Understanding of the consequences

Петюніна¹

2021

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Is the neutrophil extracellular trap-driven microvascular inflammation essential for diabetes vasculopathy?

Berezin

2016

Biomed Res Ther

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Abstract-The neutrophil extracellular traps (NETs) are defined as an extensive web consisting decondensed chromatin, which is released from activated neutrophils, as well as cytotoxic proteins, histones and microbicidal proteases that cause tissue damage. NETs contribute to endothelial damage, inflammation, thrombosis, platelet aggregation, ischemia, that are essential players in the pathobiology of diabetic complications. The objective of the review is to highlight the possible role of NETosis in early diabetes-related vasculopathy beyond cardiovascular complications. Although the clinical significance of NETosis in diabetes beyond early atherosclerosis and cardiovascular complications is not still clear, there is limited data with respect to useful to use biological markers of NETosis aimed early stratification of the diabetics at risk of disease progression. Furthermore, several inductors of NETosis might be a target for novel pharmacological approaches to delay advance in diabetes and prevent diabetes-related vasculopathy.

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The Neutrophil Extracellular Traps: The Missed Link between Microvascular Inflammation and Diabetes?

Cited by 2 publications

References 24 publications

COVID-19. Understanding of the consequences

COVID-19. Understanding of the consequences

Is the neutrophil extracellular trap-driven microvascular inflammation essential for diabetes vasculopathy?

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