The Neutrophil Life Cycle

Hidalgo, Andrés; Chilvers, Edwin R.; Summers, Charlotte; Koenderman, Leo

doi:10.1016/j.it.2019.04.013

Cited by 323 publications

(304 citation statements)

References 119 publications

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“…Neutrophils provide the first line of defense against invading pathogens. Under normal conditions they are produced at numbers of 10 11 per day and survive only a few hours to days in circulation 1,2 . In case of infection or tissue damage neutrophils migrate to the affected site in response to chemoattractants, such as CXCL8 (IL-8).…”

Section: Neutrophil Life Cyclementioning

confidence: 99%

The role of neutrophil death in chronic inflammation and cancer

2020

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Section: Neutrophil Life Cyclementioning

confidence: 99%

The role of neutrophil death in chronic inflammation and cancer

2020

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“…The mammalian neutrophil is a highly specialised cell that acts as a first responder to insults against a host immune system as well as acting in an equally important sentinel role [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…Phagocytes are key effector immune cells responsible for various biological processes; from orchestrating responses against invading pathogens to maintaining tissue homeostasis and neutrophils are the most abundant population of granulocytic phagocytes present in mammalian blood [1][2][3][4][5]. Neutrophil and heterophils (their non-mammalian counterpart) arise from a shared pool of haematopoietic stem cells and mitotic myeloid progenitor cells that can also differentiate into monocytes, eosinophils, and basophils following exposure to the relevant growth factor [1,4,6].…”

Section: Introductionmentioning

confidence: 99%

“…Neutrophil and heterophils (their non-mammalian counterpart) arise from a shared pool of haematopoietic stem cells and mitotic myeloid progenitor cells that can also differentiate into monocytes, eosinophils, and basophils following exposure to the relevant growth factor [1,4,6]. The development and life cycle of mammalian neutrophils through a continuum of multipotent progenitors to a post-mitotic mature cell has been well described and has been recently reviewed [2,4].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of receptor-ligand pairings and distribution of myeloid subpopulations across the animal kingdom reveals neutrophil evolution was facilitated by colony-stimulating factors

Pinheiro

Mawhin

Prendecki

et al. 2020

Preprint

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Neutrophils or heterophils constitute the largest population of phagocytic granulocytes in the blood of mammals and birds. The development and function of neutrophils and monocytes is primarily governed by the granulocyte colony-stimulating factor receptor family (CSF3R/CSF3) and macrophage colony-stimulating factor receptor family (CSF1R/IL34/CSF1) respectively.Using various techniques this study considered how the emergence of receptor:ligand pairings shaped the distribution of blood myeloid cell populations. Comparative gene analysis supported the ancestral pairings of CSF1R/IL34 and CSF3R/CSF3, and the emergence of CSF1 later in tetrapod lineages after the advent of Jawed/Jawless fish. Further analysis suggested that the emergence of CSF3 lead to reorganisation of granulocyte distribution between amphibian and early reptiles. However, the advent of endothermy likely contributed to the dominance of the neutrophil/heterophil in modern-day mammals and birds. In summary, we show that the emergence of CSF3R/CSF3 was a key factor in the subsequent evolution of the modern-day mammalian neutrophil.

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“…However, recent work has shown that they exhibit a longer life cycle than previously thought 4 ; reviving interest in the possibility of distinct neutrophil populations. 3,5 Spurred on by such findings, several groups have identified and characterized neutrophil subpopulations. For example, use of density gradient separation has uncovered distinct, lowdensity (LDN) and high-density neutrophil (HDN) populations, each with opposing actions in immune regulation and cancer progression.…”

Section: Introductionmentioning

confidence: 99%

CyTOF reveals phenotypically-distinct human blood neutrophil populations differentially correlated with melanoma stage

Zhu

Eggert

Araujo

et al. 2019

Preprint

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Phone: 858-752-6500 KEY POINTS• CyTOF analysis reveals 7 blood neutrophil clusters correlating with melanoma stage in treatment-naïve patients.• Neutrophil clusters by unbiased-calling are recapitulated by flow cytometry and harbor diverse phagocytic and ROS-producing capacities. VISUAL ABSTRACTSubmitted separately. ABSTRACTUnderstanding neutrophil heterogeneity and its relationship to disease progression has become a recent focus of cancer research. Indeed, several studies have identified neutrophil subpopulations associated with pro-or anti-tumoral functions. However, this work has been hindered by the lack of widely-accepted markers with which to define neutrophil subpopulations.To identify markers of neutrophil heterogeneity in cancer, we utilized single-cell cytometry by time-of-flight (CyTOF) coupled with high-dimensional analysis on blood samples from treatmentnaïve, melanoma patients. Our efforts allowed us to identify 7 blood-neutrophil clusters, including 2 previously identified individual populations. Interrogation of these neutrophil subpopulations revealed a positive trend between specific clusters and disease stage. Finally, we recapitulated these 7 blood-neutrophil populations via flow cytometry and found that they exhibit diverse capacities for phagocytosis and reactive oxygen species (ROS) production in vitro. In summary, our data provide a refined consensus on neutrophil-heterogeneity markers, enabling a prospective functional evaluation in patients with solid tumors.

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The Neutrophil Life Cycle

Cited by 323 publications

References 119 publications

The role of neutrophil death in chronic inflammation and cancer

The role of neutrophil death in chronic inflammation and cancer

Analysis of receptor-ligand pairings and distribution of myeloid subpopulations across the animal kingdom reveals neutrophil evolution was facilitated by colony-stimulating factors

CyTOF reveals phenotypically-distinct human blood neutrophil populations differentially correlated with melanoma stage

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