The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis

D’Amico, Emanuele; Zanghì, Aurora; Romano, Alessandra; Sciandra, Mariangela; Palumbo, Giuseppe; Patti, Francesco

doi:10.3390/cells8101114

Cited by 49 publications

(46 citation statements)

References 21 publications

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“…However, we investigated the associations in the subset according to adjuvant chemotherapy. Furthermore, it should be recognized that NLR is a nonspecific parameter, and it could be influenced by concomitant diseases, such as infection, autoimmune disease, or stroke 11 , 46 , 47 .…”

Section: Discussionmentioning

confidence: 99%

Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas

Gao¹,

Pan²,

Han³

et al. 2021

Cancer Biol. Med.

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Section: Discussionmentioning

confidence: 99%

Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas

Gao¹,

Pan²,

Han³

et al. 2021

Cancer Biol. Med.

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“…While T cells are recognized as the main driver of MS, elevated numbers of other peripheral leukocytes have been observed in the CNS, suggesting they may also have effector functions in MS. Specifically, a recent report demonstrated that MS patients have a higher circulating neutrophil-to-lymphocyte ratio compared to healthy controls, and the ratio increases with relapse and aggravated disability [19,20].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

Khaw

Cunningham

Tierney

et al. 2020

J Neuroinflammation

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Background: Multiple sclerosis (MS) is a chronic debilitating immune-mediated disease of the central nervous system (CNS) driven by demyelination and gray matter neurodegeneration. We previously reported an experimental autoimmune encephalomyelitis (EAE) MS mouse model with elevated serum CXCL1 that developed severe and prolonged neuron damage. Our findings suggested that CXCR2 signaling may be important in neuronal damage, thus implicating neutrophils, which express CXCR2 in abundance, as a potential cell type involved. The goals of this study were to determine if CXCR2 signaling in neutrophils mediate neuronal damage and to identify potential mechanisms of damage. Methods: EAE was induced in wild-type control and neutrophil-specific Cxcr2 knockout (Cxcr2 cKO) mice by repeated high-dose injections of heat-killed Mycobacterium tuberculosis and MOG 35-55 peptide. Mice were examined daily for motor deficit. Serum CXCL1 level was determined at different time points throughout disease development. Neuronal morphology in Golgi-Cox stained lumbar spinal cord ventral horn was assessed using recently developed confocal reflection super-resolution technique. Immune cells from CNS and lymphoid organs were quantified by flow cytometry. CNS-derived neutrophils were co-cultured with neuronal crest cells and neuronal cell death was measured. Neutrophils isolated from lymphoid organs were examined for expression of reactive oxygen species (ROS) and ROS-related genes. Thioglycolate-activated neutrophils were isolated, treated with recombinant CXCL1, and measured for ROS production. Results: Cxcr2 cKO mice had less severe disease symptoms at peak and late phase when compared to control mice with similar levels of CNS-infiltrating neutrophils and other immune cells despite high levels of circulating CXCL1. Additionally, Cxcr2 cKO mice had significantly reduced CNS neuronal damage in the ventral horn of the spinal cord. Neutrophils isolated from control EAE mice induced vast neuronal cell death in vitro when compared with neutrophils isolated from Cxcr2 cKO EAE mice. Neutrophils isolated from control EAE mice, but not Cxcr2 cKO mice, exhibited elevated ROS generation, in addition to heightened Ncf1 and Il1b transcription. Furthermore, recombinant CXCL1 was sufficient to significantly increase neutrophils ROS production. Conclusions: CXCR2 signal in neutrophils is critical in triggering CNS neuronal damage via ROS generation, which leads to prolonged EAE disease. These findings emphasize that CXCR2 signaling in neutrophils may be a viable target for therapeutic intervention against CNS neuronal damage.

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“…According to modern notions, MS is a multifactorial chronic progressive disease characterized by central nervous system damage. The process of demyelination based on mechanisms that mutually reinforce each other: inflammatory response, neurodegeneration with abnormal remyelination and axonal damage (primary or secondary) [1]. There are many publications on studies of the ratio of neutrophils to lymphocytes as a marker of inflammation in MS [1,2,5].…”

Section: Discussionmentioning

confidence: 99%

The white blood cell count (WBC) and neutrophil-to-lymphocyte ratio (NRL) in multiple sclerosis

Vivchar¹,

Акімова²,

Lapovets³

et al. 2020

J Educ Health Sport

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Introduction. Multiple sclerosis (MS) is one of the main chronic inflammatory diseases of the central nervous system that causes functional disability in people. Assessment of the state of the immune system begins with an analysis of the total number of blood leukocytes and their population composition (the number of neutrophils and lymphocytes). The ratio of neutrophils and lymphocytes (NRL) is a marker of inflammation. The aim of the study. The aim of this study was to investigate the WBC and neutrophil-to-lymphocyte ratio in patients with different forms of MS. Results. In patients with MS in 23.5% of cases the WBC is higher than 9×109/L. In 5.9% of МS cases leukopenia is observed, and in the vast majority of cases (70, 6%) the level of blood leukocytes was in the range of 4-9×109/L. Leukopenia and leukocytosis are more common in women than in men (p<0.05). Leukocytosis and leukopenia are most often found in RRMS form, while in the SPMS form patients in 93.8 % of cases the normal level of leukocytes found. MS's patients had a significantly higher NLR (p < 0.05) than the control group. No significant difference in WBC and NLR was found between groups of MS clinical forms. No association was found between NLR and an age and sex.

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The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis

Cited by 49 publications

References 21 publications

Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas

Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas

Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

The white blood cell count (WBC) and neutrophil-to-lymphocyte ratio (NRL) in multiple sclerosis

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