Organ transplantation is the great advance in medicine of the 20th century. Progresses in anti- rejection therapy have led to a globally statistical increase in its frequency. However, it is important to call attention to the progressive of patients waiting lists, as well as the constant and sometimes its frequent mortality expecting for an organ that will not arrive, the so call “Organ Shortage”. This vital problem is an evident exponent of a social behaviour, that is not conclusively defined towards organ donation. This crucial paradox of the possibility of medically turning death into life, basically required by the donation of an organ, mainly from a deceased donor; without a doubt, facilitates this intention to analyse the causes of this social phenomenon, and the current or possible proposals to overcome this persistent global health crisis.