The new endocrine WHO classification: What does this mean for thyroid cytology?

Wong, Kristine; Barletta, Justine A.

doi:10.1002/cncy.22634

Cited by 7 publications

(2 citation statements)

References 34 publications

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“…The cytology findings were as follows: clusters of tumor cells with oncocytic to clear cytoplasm, pleomorphic cells, overlapping nucleus, with nuclear features such as elongation, thickened membrane, chromatin clearing, and micronucleoli [ 21 ]. Evaluating cytology specimens for increased mitotic count and necrosis is critical, especially of the karyorrhexis type, as these factors can serve as early indicators of high-grade tumors [ 44 ]. Definitive diagnosis of DHGTC in cytology specimens is challenging, as the features may also be present in rare non-invasive tumors.…”

Section: Diagnosismentioning

confidence: 99%

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A Comprehensive Review and Insights into the New Entity of Differentiated High-Grade Thyroid Carcinoma

Harahap,

Roren,

Imtiyaz

2024

Current Oncology

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Differentiated high-grade thyroid carcinoma (DHGTC) is a new subset within the spectrum of thyroid malignancies. This review aims to provide a comprehensive overview of DHGTC, focusing on its historical perspective, diagnosis, clinical characteristics, molecular profiles, management, and prognosis. DHGTC demonstrates an intermediate prognosis that falls between well-differentiated thyroid carcinoma and anaplastic thyroid carcinoma. Previously unenumerated, this entity is now recognized for its significant impact. Patients with DHGTC often present at an older age with advanced disease and exhibit aggressive clinical behavior. Molecularly, DHGTC shares similarities with other thyroid malignancies, harboring driver mutations such as BRAFV600E and RAS, along with additional late mutations. The unique behavior and histologic features of DHGTC underscore the necessity of precise classification for prognostication and treatment selection. This highlights the critical importance of accurate diagnosis and recognition by pathologists to enrich future research on this entity further.

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Section: Diagnosismentioning

confidence: 99%

“…In addition, an infarction could also be mistaken for true tumor necrosis. However, finding these features in cytology specimens indicates a differential diagnosis of DHGTC and PDTC, and warrants further investigation [ 44 , 45 ].…”

Section: Diagnosismentioning

confidence: 99%