The New Field of Network Physiology: Building the Human Physiolome

Ivanov, Plamen Ch.

doi:10.3389/fnetp.2021.711778

Cited by 102 publications

(86 citation statements)

References 136 publications

(152 reference statements)

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“…Some commonly utilized physiological parameters (e.g., HR or VO 2 max.) may not be sensitive enough to detect specific physiological adaptations occurring in response to fatigue/training [ 94 , 95 , 96 ]. One possible explanation for this may stem from the fact that these parameters provide little information on the specific nonlinear dynamic interactions between organic subsystems involved in exercise physiology [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure and Heart Rate Responses to an Isokinetic Testing Protocol in Professional Soccer Players

Pérez-Gosalvez

José

Carrión-Otero

et al. 2022

JCM

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The aim of this study was to determine blood pressure (BP) and heart rate (HR) responses triggered during an isokinetic testing protocol in professional soccer players and compare cardiovascular parameters at completion of this isokinetic protocol with those during a treadmill test. Using purposive sampling, 63 professional soccer players were recruited. Cardiovascular responses were measured noninvasively during a bilateral testing protocol of knee flexion and extension. Treadmill ergospirometry following an incremental speed protocol was performed to analyze the same cardiovascular parameters at rest and at completion of this test. There were significant differences in diastolic blood pressure (DBP) and HR according to field position. The parameters presented high homogeneity at both competitive levels. Systolic blood pressure, mean arterial pressure, HR, and rate pressure product at completion of the treadmill test were significantly higher than those at completion of the isokinetic protocol. Intermittent isokinetic testing protocol of the knee triggers normal and safe BP and HR responses in healthy professional soccer players. The HR of the defenders was higher than those of the forwards and midfielders but was independent of the competitive level. The values of cardiovascular parameters at isokinetic protocol completion were lower than those during the treadmill test.

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Section: Discussionmentioning

confidence: 99%

Blood Pressure and Heart Rate Responses to an Isokinetic Testing Protocol in Professional Soccer Players

Pérez-Gosalvez

José

Carrión-Otero

et al. 2022

JCM

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“…In these studies, possible implications for healthy and diseased brain states have been drawn. Moreover, the important role of bursting phenomena for the understanding of brain-organ interactions have been highlighted in the perspectives article [68]. Our study complements recent research on emergent bursting dynamics in brain and organ systems by providing a simple and analytically tractable model generating collective activity bursting.…”

Section: Introductionmentioning

confidence: 61%

Collective activity bursting in networks of excitable systems adaptively coupled to a pool of resources

Franović¹,

Eydam²,

Yanchuk³

et al. 2021

Preprint

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We study the collective dynamics in a network of excitable units (neurons) adaptively interacting with a pool of resources. The resource pool is influenced by the average activity of the network, whereas the feedback from the resources to the network is comprised of components acting homogeneously or inhomogeneously on individual units of the network. Moreover, the resource pool dynamics is assumed to be slow and has an oscillatory degree of freedom. We show that the feedback loop between the network and the resources can give rise to collective activity bursting in the network. To explain the mechanisms behind this emergent phenomenon, we combine the Ott-Antonsen reduction for the collective dynamics of the network and singular perturbation theory to obtain a reduced system describing the interaction between the network mean field and the resources.

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“…Incomplete understanding of the biology of interorgan crosstalk and difficulty in deriving causation among factors responsible for homeostasis and progression of complex diseases forms the basic need for tools that could help us better understand their intricate relationships [42] (Fig. 2).…”

Section: The Cellular Secretome In Interorgan Crosstalkmentioning

confidence: 99%

“…While attempts are made in systems biology to transition from the micro‐, subcellular, and cellular interactions to whole‐human epidemiological observations, there is a wide gap at the level of horizontal network interactions across organ systems [42]. An imperative challenge is thus to gain an understanding in how behavior at the molecular level determines physiological function at the level of not only cells but tissues and organs.…”

Section: Deriving Causality One Network At a Timementioning

confidence: 99%

Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases

Trapečar

2021

FEBS Letters

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Metabolic and inflammatory disorders such as autoimmune and neurodegenerative diseases are increasing at alarming rates. Many of these are not tissue‐specific occurrences but complex, systemic pathologies of unknown origin for which no cure exists. Such complexity obscures causal relationships among factors regulating disease progression. Emerging technologies mimicking human physiology, such as microphysiological systems (MPSs), offer new possibilities to provide clarity in systemic metabolic and inflammatory diseases. Controlled interaction of multiple MPSs and the scalability of biological complexity in MPSs, supported by continuous multiomic monitoring, might hold the key to identifying novel relationships between interorgan crosstalk, metabolism, and immunity. In this perspective, I aim to discuss the current state of modeling multiorgan physiology and evaluate current opportunities and challenges.

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The New Field of Network Physiology: Building the Human Physiolome

Cited by 102 publications

References 136 publications

Blood Pressure and Heart Rate Responses to an Isokinetic Testing Protocol in Professional Soccer Players

Blood Pressure and Heart Rate Responses to an Isokinetic Testing Protocol in Professional Soccer Players

Collective activity bursting in networks of excitable systems adaptively coupled to a pool of resources

Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases

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