The new insight of prostate-specific antigen reduction during finasteride therapy in aging men

Ding, Xu; Ding, Jie; Zhu, Yunkai; Qian, Xiaoqiang; Duan, Liujian; Qi, Jun

doi:10.1007/s40520-015-0512-3

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…The PSA levels were not the true PSA levels. Some of the patients were undergoing treatment with 5-alpha reductase inhibitors like Finasterid (Finasterid 5 mg, PharmaCoDane, Herlev, Denmark) or Dutasterid (Avodart, PharmaCoDane, Herlev, Denmark) which affects the PSA levels, halving the actual level (16).…”

Section: Discussionmentioning

confidence: 99%

Biparametric versus multiparametric MRI in the diagnosis of prostate cancer

Thestrup

Løgager

Baslev

et al. 2016

Acta Radiologica Open

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BackgroundSince multiparametric magnetic resonance imaging (mp-MRI) of the prostate exceeds 30 min, minimizing the evaluation time of significant (Gleason scores > 6) prostate cancer (PCa) would be beneficial. A reduced protocol might be sufficient for the diagnosis.PurposeTo study whether a short unenhanced biparametric MRI (bp-MRI) matches mp-MRI in detecting significant PCa.Material and MethodsA total of 204 men (median age, 65 years; mean ± SD, 64.1; range 45–75 years; median serum PSA level, 14 ng/mL; range, 2.2–120 ng/mL; median prostate volume, 60 mL; range, 23–263 mL) fulfilled the criteria for being enrolled. They underwent mp-MRI and prostate biopsy from January through June 2014. Of the included patients, 9.3% underwent prostatectomy, 90.7% had TRUS-bx, and 10.8 had MRI-targeted TRUS-bx. Two radiologists separately assessed the mp-MRI examination (T2-weighted [T2W] imaging, diffusion-weighted imaging [DWI], apparent diffusion coefficient map [ADC-map] and dynamic contrast-enhanced imaging [DCE]). Two months later, the bp-MRI version (T2W imaging, DWI, and ADC-map) was evaluated.ResultsReader 1: Assessing mp-MRI: 0 false negatives, sensitivity of 1, and specificity 0.04. Assessing bp-MRI: four false negatives, sensitivity of 0.94, and specificity 0.15. Reader 2: Assessing mp-MRI: five false negatives, sensitivity of 0.93, and specificity 0.16. Assessing bp-MRI: three false negatives, sensitivity of 0.96, and specificity 0.15. Intra-reader agreement Cohen’s Kappa (κ) was 0.87 for reader 1 (95% confidence interval [CI], 0.83–0.92) and 0.84 for reader 2 (95% CI 0.78–0.89).ConclusionBp-MRI is as good as mp-MRI at detecting PCa. A large prospective study seems to be strongly warranted.

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Section: Discussionmentioning

confidence: 99%

Biparametric versus multiparametric MRI in the diagnosis of prostate cancer

Thestrup

Løgager

Baslev

et al. 2016

Acta Radiologica Open

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“…Consequently, since the 1990 th 5-alpha-reductase inhibitors like Finasteride were used to treat prostate hyperplasia, with a castration like effect [3,4]. In a new study it shows, that Finasteride could reduce the PSA level by approximately 40 % during therapy, however in those cases the volume of the prostate hyperplasia was not affected and did not correlate with the PSA [5]. There is an overall link between prostate cancer and PSA serum levels.…”

Section: Introductionmentioning

confidence: 99%

Stabilization of Prostate Cancer with Amanita phalloides: Intervals with 5-Alpha-Reductase Inhibitors and Melatonin to Circumvent Resistance: Case Report

Riede

2016

BJMMR

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Aims: Amanita phalloides contains alpha-amanitin, inhibiting RNApolymeraseII. Due to overexpression of switch genes in tumor cells, RNApolymeraseII is used to full extent there. Partial inhibition with amanitin influences tumor cell-but not normal cell-activity. A patient with diagnosed prostate cancer was treated successfully for six years with Amanita alone, prostate specific antigen levels increased slowly. However, the necessary dose for stabilization of the level increased during this time. To circumvent further habituation or resistance, other therapeutics were applied in intervals. Presentation of Case: Inhibitors of 5-alpha-reductase were applied in intervals of pausing Amanita. They can further stabilize the prostate antigen level, but tumor cells became resistant to this drug after a few months. The patient suffered under severe side effects. Melatonin was applied in one interval together with Amanita. It shows no additional side effect, but no additional advantage for the patient occurs. Discussion and Conclusion: Amanita is the drug for long term stabilization of a tumor patient. Fast occurrence of resistance was never observed so far. 5-alpha-reductase inhibitors can be

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Improving prostate biopsy decision making in Mexican patients: Still a major public health concern

Amaya-Fragoso

García-Pérez

2021

Urologic Oncology: Seminars and Original Investigations

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The new insight of prostate-specific antigen reduction during finasteride therapy in aging men

Abstract: When baseline PSA level was greater than 4 ng/mL, the doubling rule could be used for screening. When baseline PSA level was less than 4 ng/Ml, the doubling rule might not be an accurate predictor. We can use the PSA rise from nadir or proPSA to predict prostate cancer.

Cited by 3 publications

References 27 publications

Biparametric versus multiparametric MRI in the diagnosis of prostate cancer

Biparametric versus multiparametric MRI in the diagnosis of prostate cancer

Stabilization of Prostate Cancer with Amanita phalloides: Intervals with 5-Alpha-Reductase Inhibitors and Melatonin to Circumvent Resistance: Case Report

Improving prostate biopsy decision making in Mexican patients: Still a major public health concern

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