2009
DOI: 10.1254/jphs.08292sc
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The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis

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Cited by 6 publications
(4 citation statements)
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“…UR-1505 inhibits αCD3/CD28-induced, but not JAK/STAT-induced T cell proliferation and IL-5 as well as IFNγ expression. UR-1505 shows anti-inflammatory properties in rat colitis models [ 134 ]. Triflusal , another salicylic acid derivative, inhibits not only NFATc-DNA complex formation, but additionally NF-κB activation [ 135 ].…”
Section: Small Molecular Inhibitorsmentioning
confidence: 99%
“…UR-1505 inhibits αCD3/CD28-induced, but not JAK/STAT-induced T cell proliferation and IL-5 as well as IFNγ expression. UR-1505 shows anti-inflammatory properties in rat colitis models [ 134 ]. Triflusal , another salicylic acid derivative, inhibits not only NFATc-DNA complex formation, but additionally NF-κB activation [ 135 ].…”
Section: Small Molecular Inhibitorsmentioning
confidence: 99%
“…Calcineurin inhibitors, such as cyclosporine A (CsA) and tacrolimus (FK506), have been used to treat graft rejection and autoimmune diseases, including atopic dermatitis, rheumatoid arthritis, and lupus nephritis ( 27 32 ). More inhibitors specifically targeting NFATs (such as VIVIT peptide, INCA-1, ST-1959, and UR-1505) were developed and are being verified; however, they are yet to be analyzed in suitable animal models of autoimmune diseases to investigate their potential of ameliorating diseases ( 33 36 ).…”
Section: Introduction: Classical Nfatsmentioning
confidence: 99%
“…These findings provided two new insights into the pathogenesis of IBD at that time: the first one is that a genetic factor lead to mucosal inflammation that resembles IBD and the second one is that altered immune responses contribute to the initiation and chronification of IBD. The most widely used IBD animal models are colitis chemically induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) (10), oxazolone (11), and dextran sodium sulfate (DSS) (12,13) (Table 1). Importantly, transfer of a T cell population (CD4 + CD45RB high T cells) that lacks regulatory T cells into scid or Rag −/− animals induced colonic inflammation (14) ( Table 1).…”
Section: Introductionmentioning
confidence: 99%