The new two-dimensional light scattering method for recognition of pharmaceutical enantiomers

Vladimirovich, Syroeshkin Anton; Valerievna, Levitskaya Olga; Vadimovna, Pleteneva Tatiana; Uspenskaya, E. V.; Antonovna, Tribot-Laspiere Maria; Vladimirovna, Tarabrina Irina

doi:10.7324/japs.2020.101204

Cited by 1 publication

(2 citation statements)

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“…The equipment, based on a backscatter detection solution, consists of a small-sized radiator with integrated high-spectral-density LEDs and a video camera. New-generation LEDs were used to probe the sample surface, providing a power density of up to 50 mVt/cm 2 in the 360-410 nm range and a spectral line width of up to 2-4 nm (model AA3528LVBS/D, type C503B-BCN-CV0Z0461, CreeLED, Inc., Zhuhai, China) (Figure 6) [22].…”

Section: D Light Scattering (2d-ls) Methodsmentioning

confidence: 99%

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Exploring the Effects of Cramped-Impact-Type Mechanical Action on Active Pharmaceutical Ingredient (Levofloxacin)—Prospects for Pharmaceutical Applications

Uspenskaya,

Simutina,

Kuzmina

et al. 2023

Powders

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Mechanochemistry is one of the ten great discoveries of green chemistry methods for synthesizing new substances. A drug substance from the fluoroquinolone group was exposed to high-intensity mechanical impacts using a laboratory knife mill for 21 min and constantly monitored by analyzing samples extracted every 3 min with DLS, SLS, LALLS, 2D-LS, optical and digital microscopy, FTIR, and Spirotox methods. A dispersity phenomenon was detected in an area where catastrophic dislocations formed and multiplied via laser methods. The positive correlation between the temperature of deformation and stress was demonstrated, similar to a typical stress–strain curve of a Bochvar–Oding curve and Young’s modulus: the angular coefficient of the straight section to OX was tgα = 10 min−1. Z-Average, ζ-potential, and polydispersity index dependences were represented as discontinuous periodic oscillations analogous to the defect and impurity transitions near the dislocation core. Deformation r from the high-intensity mechanical impact resulted in covalent bonds showing hyper- and hypochromic effects under FTIR spectra, a bathochromic shift of the maximum, and an oscillation emission at 3240 cm−1. A 2D-LS fingerprint diagram obtained via the topological convolution of the light scattering matrix made it possible to distinguish the off-loading samples from the native substance. The investigation of the dissolution kinetics in water via laser diffraction led to conclusions about the limiting diffusion stage and the acceleration of the mechanoactivation of the solid body’s dissolution under both linear and plastic deformation. The acceleration of obsEa of the cell death process in the temperature range from 296 to 302 K indicated a significant (2.5-fold) decrease in the toxicity of the aqueous 9 mM (1:3) sample solution at 21 min compared to that of the native levofloxacin. Adherence to the mechanochemistry laws provides an opportunity for drug repositioning to change their brand status by identifying new physicochemical and biological properties.

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Section: D Light Scattering (2d-ls) Methodsmentioning

confidence: 99%

“…Powders 2023, 3, FOR PEER REVIEW 6 AA3528LVBS/D, type C503B-BCN-CV0Z0461, CreeLED, Inc., Zhuhai, China) (Figure 6) [22]. The resulting light scattering patterns were processed using ten topological descriptors similar to the Wiener (W) and Balaban (J) QSAR descriptors, modified by Trinajstic (l) (Table 1).…”

Section: D Light Scattering (2d-ls) Methodsmentioning

confidence: 99%