The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications

Abstract

The new WHO classification takes into account the recent findings on the origin, pathogenesis, and prognosis of different ovarian cancer subtypes. The tubal origin of hereditary and some non-hereditary high-grade serous cancers is mentioned in contrast to the hitherto theory of mesothelial origin of tumors. Seromucinous tumors represent a new entity.

Changes in the Management and Prognosis of Ovarian Cancer Due to the New FIGO and WHO Classifications: A Case Series Observational Descriptive Study. Seven Years of Follow-up

“…The seromucinous group comprises the former endocervicaltype mucinous BOT, although the new WHO classification requires at least 2 types of Müllerian differentiation for the diagnosis. 11 In our sample, we found 1.85% of seromucinous borderline tumors (0.93% from endocervical MBOT and the other 0.93% from mixed epithelial borderline tumors). In this new category (seromucinous borderline ovarian tumour), there are areas with intraepithelial cancer, in contrast to SBOT.…”

“…11 Apart from the different nomenclature, the main change in the serous group was the increase in the HGSC percentage.…”

“…In the last 2 years, most recent studies refer to the changes between the previous and the current classifications of OV, FT, and P cancer 8,9,11 ; however, there has been no demonstration, through a statistical study applied to an affected population of changes in the management of these tumors by gynecologic oncologists. We consider that this insight is useful to all the gynecologic oncologists who need to make decisions every day regarding patients with OV, FT, and P cancer.…”

Immunohistochemical Expression of Glut-1 in Epithelial Ovarian Tumors: Correlation With the Clinicopathological Factors and Tumor Proliferative Marker Pcna.

“…Tumors were staged according to the FIGO (The International Federation of Gynecology and Obstetrics staging system) [23]. Histological typing and grading have followed the World Health Organization classification (WHO) criteria [4]. The ethical committee of Zagazig University approved this study and all patients wrote a consent of agreement prior to their inclusion in this study.…”

“…constitute the majority of ovarian tumors [3] WHO classified ovarian surface epithelial tumors histologically into: serous, mucinous, transitional cell, endometrioid, clear cell, mixed, squamous, and undifferentiated subtypes [4].…”