The New York High-Risk Project

Erlenmeyer‐Kimling, L.; Adamo, Ulla Hilldoff; Rock, Donald A.; Roberts, Simone A.; Bassett, Anne S.; Squires-Wheeler, Elizabeth; Cornblatt, Barbara A.; Endicott, Jean; Pape, Sky; Gottesman, Irving I.

doi:10.1001/archpsyc.1997.01830240052008

Cited by 143 publications

(26 citation statements)

References 30 publications

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“…Although family studies have generally found these two disorders to ''breed true,'' a small degree of familial overlap has frequently been observed. Recent family study data have further supported some degree of overlap (44). Only the identification of specific genes will resolve this question.…”

Section: Discussionmentioning

confidence: 99%

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

Kelsoe

Spence

Loetscher

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

236

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Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown; however, numerous family, twin, and adoption studies have argued for a substantial genetic contribution. We have conducted a genome survey of bipolar disorder using 443 microsatellite markers in a set of 20 families from the general North American population to identify possible susceptibility loci. A maximum logarithm of odds score of 3.8 was obtained at D22S278 on 22q. Positive scores were found spanning a region of nearly 32 centimorgans (cM) on 22q, with a possible secondary peak at D22S419. Six other chromosomal regions yielded suggestive evidence for linkage: 3p21, 3q27, 5p15, 10q, 13q31-q34, and 21q22. The regions on 22q, 13q, and 10q have been implicated in studies of schizophrenia, suggesting the possible presence of susceptibility genes common to both disorders.

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Section: Discussionmentioning

confidence: 99%

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

Kelsoe

Spence

Loetscher

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

236

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“…Our criterion diagnosis of SRI consists of several disorders that research has demonstrated to be both conceptually and genetically related to schizophrenia and includes schizophrenia, schizoaffective disorder, and Cluster A personality disorders (Erlenmeyer-Kimling et al, 1997). A premorbid group, consisting of individuals from the New York High-Risk Project (NYHRP; Erlenmeyer-Kimling & Cornblatt, 1988;Erlenmeyer-Kimling et al, 1984, 1997, was used to assess SzP's ability to identify individuals who would later (mean time to diagnosis ϭ 14 years) experience the onset of SRI. A postmorbid group, consisting of individuals from the Torrey-Gottesman National Institute of Mental Health (NIMH; Torrey, Bowler, Taylor, & Gottesman, 1994) study of identical twins discordant for schizophrenia, as well as members of Gottesman and Shields's (1972) Maudsley Twin Study, was created to test the construct validity of the scale.…”

Section: Methodsmentioning

confidence: 99%

The Schizophrenia Proneness (SzP) scale: An MMPI‐2 measure of schizophrenia liability

2003

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We examined the psychometric properties and construct validity for a Minnesota Multiphasic Personality Inventory-2 Schizophrenia Proneness (SzP) scale (Bolinskey et al., 2001) and provided normative statistics. Premorbid participants were offspring of parents with schizophrenia-related illness (SRI), with comparison groups of offspring of parents with major affective disorders and offspring of normals. Postmorbid participants were twins affected with SRI; their unaffected relatives served as a comparison group. Results suggest that an SzP T score of 65 or above is an effective indicator of personality processes associated with increased liability to developing SRI.

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“…Erlenmeyer- Kimling et al (1995), por su parte, ilustran la agregación familiar de los trastornos de personalidad del grupo A del DSM en descendientes de esquizofrénicos aunque, si bien diversos estudios refieren la presencia específica del trastorno esquizotípico de la personalidad (Pamas et al 1993;Maier, Lichtermann, Mingues y Heun, 1994), su trabajo revela la mayor prevalencia de los trastornos del grupo A (esquizotípico, paranoide y esquizoide) en conjunto. Algunos investigadores (como por ejemplo Siever, Keefe y Bernstein, 1991), observando la prevalencia del trastorno esquizotípico entre los familiares de pacientes no esquizofrénicos (Yeung, Lyons, Waternaux, Faraone y Tsuang, 1993), concluyen que no todos los casos de esquizotipia se encuentran genética-mente ligados a la esquizofrenia, con lo que sugieren que la relación personalidad esquizotípica-espectro esquizofréni-co, en términos de la teoría de conjuntos, tiene un carácter intersectivo, ya que aunque ambos conceptos comparten rasgos, ninguno de los dos contiene enteramente al otro.…”

Section: Precursores Conductuales Infantiles De La Esquizotipiaunclassified

“…Además, permiten la sistematicidad y uniformidad de las evaluaciones, con las ventajas que esto supone para conjeturar sobre posibles etiologías, asegurar la detección de todos los casos que presenten patología y corroborar el diagnóstico diferencial en presencia de ambigüedades Pamas et al, 1993;Erlenmeyer et al,1995).…”

Section: Introductionunclassified

Precursores conductuales infantiles de los trastornos del espectro esquizofrénico : esquizofrenia y trastorno esquizotípico de la personalidad

Solà¹,

Barrantes‐Vidal²,

Obiols³

1999

RPPC

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Dada la extensa y creciente aparición de trabajos sobre marcadores bioconductuales de los trastornos del espectro esquizofrénico, hemos pretendido realizar una tarea de síntesis de los datos aportados y orientarla a la cuestión de posibles diferencias en cuanto a precursores de la evolución hacia el trastorno esquizotípico y la esquizofrenia. Después de situar conceptualmente a los estudios de riesgo elevado, se revisan en primer lugar los trabajos clásicos y más recientes sobre marcadores pslcobiológicos dentro del paradigma del riesgo genético para la esquizofrenia y, en segundo lugar, se presentan los hallazgos de los trabajos que han tomado como marcadores de riesgo variables no sólo genéticas y que se han centrado en el estudio de las condiciones leves del espectro (esto es, esquizotipia y trastorno esquizotípico de la personalidad). Por último se discuten las limitaciones de los trabajos existentes y también sus implicaciones teóricas y aplicadas.Palabras clave: esquizofrenia, esquizotipia, marcadores conductuales, riesgo genético, riesgo bioconductual. Behavioural childhood precursors ofschizophrenia spectrum disorders: schizophrenia and schizotypal personality disorderGiven the wide and growing appearance of studies on biobehavioural markers of schizophrenia spectrum disorders, we have pursued to synthesise the data focusing on the possible differences in such markers as precursors of development towards schizotypal disorder and schizophrenia. Following a conceptual seting of high-risk studies we first outline classic and recent works about psychobiological markers from the genetic risk paradigm for schizophrenia and, secondly, we present findings coming from studies that have used other than genetic markers and have focused on the analysis of the soft conditions of the spectrum (i.e., schizotypy and schizotypal personality disorder). Lastly, limitations and theoretical and applied implications of these studies are discussed.

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The New York High-Risk Project

Abstract: The familial liabilities to schizophrenia and affective disorders show specificities and commonalities, differing markedly from each other in their expression of some disorders and sharing others. Patterns of comorbidity are generally, although not entirely, similar to these liabilities.

Cited by 143 publications

References 30 publications

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

The Schizophrenia Proneness (SzP) scale: An MMPI‐2 measure of schizophrenia liability

Precursores conductuales infantiles de los trastornos del espectro esquizofrénico : esquizofrenia y trastorno esquizotípico de la personalidad

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