The Newest Generation of Drug-eluting Stents and Beyond

Objective The National interventional Council of Cardiological Society of India (CSI–NIC) is the society representing all the practising interventional cardiologists across country. Every year National interventional council collects the data of coronary and non-coronary interventions across all the cath labs in the country and data will be presented at annual meet. This Data will show the burden of disease, number of interventions and adaption of various newer procedures from various centers across India. Methods Retrospective collection of data pertaining to all the coronary and non coronary interventions across India for the period of 1 year from January 1 st 2018 to December 31 st 2018. This data was collected by various methods like online submission, email based collection of data and filled proforma from all working cath labs all over the country. All the data was compiled and analysed for various interventional procedures. Results A total of 4,38,351 percutaneous interventions were performed in 1 year period during 2018 and utilized 5,78,164 coronary stents with a 13.14% increase in number of procedures from 709 centers. The major indication for PCI was post myocardial infarction. There was an increase in use of adjunctive imaging techniques along with PCI,increase in number of Transcatheter aortic valve replacements (TAVR) across country. Conclusions The prevalence and number of percutaneous coronary interventions for coronary artery disease were on rising trend year by year. There was an increase in number of multivessel PCI, compelx PCI, intravascular imaging guided precision PCI and the number of TAVR performed compared to previous year.

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“…This could be considered as success of newer generation DES which have much less TLR requirement on follow up due to less restenosis rates. 11 …”

Section: Discussionmentioning

confidence: 99%

National interventional council data for the year 2018-India

Arramraju

Janapati

Kumar

et al. 2020

Indian Heart Journal

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“…From BMS to the development of the second-generation DES, coronary stents have undergone a remarkable transformation with the aim to avoid both restenosis and thrombosis. The risk, however, is still present attributed to the stent being perceived as foreign prosthesis and subsequent neointima proliferation as the likely underlying pathology [8]. Variable investigations have looked into the predictors of ISR and recognized small vessel size, stents of increased length, diabetes mellitus, history of bypass surgery, and complex looking lesion as some of the metrics [9] Although DES have been in Pakistan since 2002, few pieces of research have looked into the phenomenon and have been mostly centered around possible interventions like drug-eluting balloon and bioresorbable vascular scaffolds in the wake of ISR [10].…”

Section: Discussionmentioning

confidence: 99%

Early Restenosis of Sirolimus-eluting Stent: An Unusual Case of a Hyperthyroid Patient

Shabbir¹,

Baloch²,

Mustafa³

et al. 2019

Cureus

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The presentation of atherosclerosis with concomitant hyperthyroidism is not uncommon. Hyperthyroidism predisposes to worse cardiovascular pathologies like systolic hypertension, atrial fibrillation, and hypercoagulability. Drug-eluting stents, on the other hand, have emerged as a miracle treatment choice for patients having atherogenic conditions. They have the highest success rates when it comes to minimizing in-stent restenosis (ISR) during shortterm follow-up. There is scarce literature that assesses the correlation of multinodular goiter (MNG) to ISR, especially in Pakistan, and thus any probable association between the two is left untouched. We report a case of a 57-year-old female who is a known hyperthyroid with a massive MNG, presenting with worsening chest pain. She had undergone sirolimus-eluting stent (SES) implantation in left anterior descending artery (LAD) six months back. Cardiac catheterization confirmed restenosis of the SES in the LAD, along with the occlusion of left circumflex and right coronary artery, accompanied by grade I diastolic dysfunction and mild aortic regurgitation on echocardiography.

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Section: Implantable Device With Biodegradable Materialsmentioning

confidence: 99%

“…Significant progress has been made especially in interventional cardiology [114]. New drug-eluting stents have been developed to not only minimize neointimal hyperplasia and reduce restenosis after revascularization, but also minimize stent thrombosis, a problem that was observed at higher frequency with the first generation stents [114]. Recently, Lih et al developed a new approach to prevent acid-induced inflammatory responses associated with biodegradable PLGA, by neutralizing the acidic environment using oligo(lactide)-grafted magnesium hydroxide (Mg(OH) 2 ) nanoparticles [115].…”

Section: Implantable Device With Biodegradable Materialsmentioning

confidence: 99%

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

2020

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Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. Objective: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. Method: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. Results: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. Conclusion: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.

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The Newest Generation of Drug-eluting Stents and Beyond

Cited by 112 publications

References 37 publications

National interventional council data for the year 2018-India

National interventional council data for the year 2018-India

Early Restenosis of Sirolimus-eluting Stent: An Unusual Case of a Hyperthyroid Patient

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

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