1991
DOI: 10.1016/0021-9150(91)90191-5
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The NHLBI Twin Study: heritability of apolipoprotein A-I, B, and low density lipoprotein subclasses and concordance for lipoprotein(a)

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Cited by 115 publications
(61 citation statements)
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“…The heritability of 71% in Caucasians, which according to our analysis is entirely due to the contribution of the apo(a) locus, is lower than in most previous studies which have estimated h 2 values of > 90% from twin analysis 10,38,39 and correlation among sibs. 11,12 Determination of h 2 by correlation analysis of sib data are generally too high and only yield an upper boundary for the estimate of heritability 26 (p 164).…”
Section: Discussioncontrasting
confidence: 81%
See 1 more Smart Citation
“…The heritability of 71% in Caucasians, which according to our analysis is entirely due to the contribution of the apo(a) locus, is lower than in most previous studies which have estimated h 2 values of > 90% from twin analysis 10,38,39 and correlation among sibs. 11,12 Determination of h 2 by correlation analysis of sib data are generally too high and only yield an upper boundary for the estimate of heritability 26 (p 164).…”
Section: Discussioncontrasting
confidence: 81%
“…Nevertheless, all previous point estimates were higher. [10][11][12]38,39 The contribution of the apo(a) locus to Lp(a) level variability in Caucasians is also much less, being about 70% in the present analysis as opposed to > 90% in three previous studies. 11,12,15 Obviously the contribution to the phenotypic variability in Lp(a) levels of the apo(a) locus alone cannot be larger than the total genetic contribution.…”
Section: Discussioncontrasting
confidence: 51%
“…19 - 23 A recent study of twin congruity in the National Heart, Lung, and Blood Institute Twin Study indicated no statistically significant differences in LDL size between the monozygotic and dizygotic twins. 18 The magnitude of change in LDL size in the present study was far greater than we had initially predicted. We saw a change of at least one band size in 56% of this population within a 3-year period.…”
Section: Discussioncontrasting
confidence: 55%
“…Data from twin studies show that there is a strong heritability for apoB and LDL levels (5,6), and numerous genome scans have attempted to identify loci linked to lipid levels. A recent summary of the results from various lipid genome scans lists significant or suggestive evidence for linkage on chromosomes 1, 2, 3, 6, and 11 for apoB and on chromosomes 1,3,4,5,6,10,11,13,15,17,19, and X for LDL (7).…”
mentioning
confidence: 99%
“…A recent summary of the results from various lipid genome scans lists significant or suggestive evidence for linkage on chromosomes 1, 2, 3, 6, and 11 for apoB and on chromosomes 1,3,4,5,6,10,11,13,15,17,19, and X for LDL (7). In addition, linkage scans for loci influencing both traits have identified regions on chromosomes 2, 11, and 18 (7).…”
mentioning
confidence: 99%