The Nitration of 4,4'-Dichlorodiphenyl

Abstract

Tephrosinmonocarboxylic Acid.-When isotephrosindicarboxylic acid was boiled for one-half minute with diphenyl ether, tephrosinmonocarboxylic acid was formed in essentially the same yield as recorded for tephrosindicarboxylic acid.1 As obtained from the cooled diphenyl ether solution upon the addition of methanol the acid melted at 266-268°, and when it was mixed with an authentic sample of tephrosinmonocarboxylic acid no depression of the melting point occurred. It also gave the characteristic scarlet color with ferric chloride that is obtained with tephrosinmonocarboxylic acid. Summary A crystalline material, shown by its composition and certain of its derivatives to be an isomer of tephrosin, has been obtained from a sample of Peruvian cubé root. This substance has been designated as isotephrosin. The structural difference between tephrosin and isotephrosin exists in the orientation of the hydrogen and hydroxyl groups on carbons 7 and 8 in the structure given in the text.