The nitrous-oxide method for determining coronary blood flow in man

Rowe, George G.

doi:10.1016/0002-8703(59)90344-8

Cited by 38 publications

(9 citation statements)

References 48 publications

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“…Principles involved in the detection of heterogeneSlyke Oximeter § ous coronary blood flow by inert gas techniques have been discussed in detail in recent reviews -/ 1 0 196 (12)(13)(14)(15)(16)(17). Of for partial pressure of inert gas is always reached beright atrial H2 tween tissue and blood at the capillary level, i.e., that tissue-blood gas exchange is limited solely by perfusion Mass.…”

Section: Discussion Saturationmentioning

confidence: 99%

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Effects of heterogeneous myocardial perfusion on coronary venous H2 desaturation curves and calculations of coronary flow

Klocke¹,

Koberstein²,

Pittman³

et al. 1968

J. Clin. Invest.

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A B S T R A C T The present investigation was intended to evaluate myocardial inert gas desaturation curves for manifestations of heterogeneous coronary perfusion. The test gas was hydrogen (H2) and blood H, analyses were performed with a gas chromatograph capable of detecting small but prolonged venous-arterial H2 differences produced bv areas of reduced flow. Curves were initially obtained after 4-min left ventricular infusions of H11-saturated saline in six patients with arteriographically proven coronary artery disease, three patients with normal coronary arteries, and nine closed-chest dogs. The dogs were studied before and after embolic occlusion of a portion of the left coronary artery. Although the slopes of their semilogarithmically plotted venous desaturation curves varied with time before embolization, they showed more distinct deviations from single exponentials after embolization (after H2 concentrations had fallen below 15% of their initial values). The human curves divided similarly, those from coronary artery patients deviating appreciably from single exponentials. A similar separation wlas also evident in studies of coronary venous-arterial H2 differences after 20 min of breathing 2%11 H; data were obtained in four dogs before and after coronary embolization, and in three normal patients, and five patients with coronary artery disease. Additional data indicated that the This work was presented in part at the 40th Annual

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Section: Discussion Saturationmentioning

confidence: 99%

“…Heterogeneity of coronary flow also has important implications for numerical calculations of flow (2,4,7,(12)(13)(14)(15)(16)(17)22). When desaturation follows test gas breathing, flow is calculated from the change in tissue gas concentration and the mean venous-arterial gas difference.…”

Section: Discussion Saturationmentioning

confidence: 99%

Effects of heterogeneous myocardial perfusion on coronary venous H2 desaturation curves and calculations of coronary flow

Klocke¹,

Koberstein²,

Pittman³

et al. 1968

J. Clin. Invest.

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show abstract

“…Twenty adult mongrel dogs weighing [15][16][17][18][19][20][21][22][23][24][25] kg were evaluated in this study. These animals were anesthetized with intravenous pentobarbital, intubated and ventilated on a Harvard respirator.…”

Section: Methodsmentioning

confidence: 99%

Relation between left coronary artery stenosis and regional left ventricular function.

Sutton¹,

Frye²,

Smith³

et al. 1978

Circulation

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The effect of stenosis of the left main and proximal anterior descending coronary arteries on anterior left ventricular wall dynamics was investigated in 70 patients with ischemic heart disease by the use of roentgen videometric analysis of left ventricular angiograms. In all patients with ischemic heart disease, mean values for peak rate of systolic wall thickening and diastolic wall thinning were significantly smaller than normal (P less than 0.01). In patients without infarction, there was no correlation between peak rate of systolic anterior wall thickening and stenosis of the coronary artery supplying it, but there was a significant reduction in peak rate of diastolic wall thinning (P less than 0.01) in patients with stenosis greater than 90%; this difference was not apparent at any lower degree of stenosis. This population could not be recognized by any other parameter of global or regional ventricular function; thus, diastole is more sensitive to regional left ventricular dysfunction than systole.

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“…A cuffed endotracheal tube was connected to an appropriate series of flutter valves and three-way stopcocks so that expired air could be collected in a Tissot spirometer for determination of cardiac output by the Fick principle, and a mixture of 15 per cent nitrous oxide, 21 per cent oxygen, and 64 per cent nitrogen could be inhaled for determination of coronary blood flow by the nitrous oxide saturation technique. 24 The partition coefficient for distribution of nitrous oxide between blood and heart muscle was assumed to be one. Blood pR was determined by the Cambridge Model R pR meter.…”

Section: Methodsmentioning

confidence: 99%

Systemic and coronary hemodynamic effects of an amine oxidase inhibitor and of serotonin

Rowe

Afonso

Castillo

et al. 1963

Clin Pharma and Therapeutics

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The nitrous-oxide method for determining coronary blood flow in man

Cited by 38 publications

References 48 publications

Effects of heterogeneous myocardial perfusion on coronary venous H2 desaturation curves and calculations of coronary flow

Effects of heterogeneous myocardial perfusion on coronary venous H2 desaturation curves and calculations of coronary flow

Relation between left coronary artery stenosis and regional left ventricular function.

Systemic and coronary hemodynamic effects of an amine oxidase inhibitor and of serotonin

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