2016
DOI: 10.1002/eji.201546015
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The Nlrp3 inflammasome, IL‐1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice

Abstract: Infection of C57BL/6 mice with most L. major strains results in a healing lesion and clearance of parasites from the skin. Infection of C57BL/6 mice with the L. major Seidman strain (LmSd) isolated from a patient with chronic lesions, despite eliciting a strong Th1 response, results in a non-healing lesion, poor parasite clearance, and complete destruction of the ear dermis. We show here that in comparison to a healing strain, LmSd elicited early upregulation of IL-1β mRNA and IL-1β producing dermal cells and … Show more

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Cited by 124 publications
(161 citation statements)
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“…However, the authors of this study did not find any role for the NLRP3 inflammasome in clearing L. major , suggesting a species-specific role for the NLRP3 inflammasome. The results of a more recent study using a non-healing strain of L. major infection in C57BL/6 mice show that NLRP3 inflammasome–induced IL-1β promotes lesions through recruitment of neutrophils at the site of the infection [100]. Thus, mice deficient in the inflammasome components are significantly less protected from L. major infection in this model system.…”
Section: Leishmaniasismentioning
confidence: 91%
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“…However, the authors of this study did not find any role for the NLRP3 inflammasome in clearing L. major , suggesting a species-specific role for the NLRP3 inflammasome. The results of a more recent study using a non-healing strain of L. major infection in C57BL/6 mice show that NLRP3 inflammasome–induced IL-1β promotes lesions through recruitment of neutrophils at the site of the infection [100]. Thus, mice deficient in the inflammasome components are significantly less protected from L. major infection in this model system.…”
Section: Leishmaniasismentioning
confidence: 91%
“…Despite several studies of IL-1 and IL-18, the roles of NLRs (the major regulators of IL-1 cytokine family) during Leishmania infections remain largely unknown. Thus far, only the NLRP3 inflammasome has been shown to be involved in modulating immune responses against Leishmania infections [97100]. The results of these studies suggest that the NLRP3 inflammasome is directly involved in processing and releasing IL-1β and IL-18 during Leishmania infection in vitro and in vivo (Figure 2b).…”
Section: Leishmaniasismentioning
confidence: 97%
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“…Recently, L. major Seidman strain (LmSd) -infected C57BL/6 mice has resulted in a non-healing lesion. The most likely causes are the association of NLRP3 inflammasome-dependent IL-1β with localized neutrophil recruitment [120]. Considerably more work will need to be done to expand our current knowledge of inflammasome activation or regulation by protozoan parasites or their components to identify additional host molecules or parasitic protozoan components that activate and manipulate the NLRP3 inflammasome complex.…”
Section: Inflammasome-mediated Pyroptotic and Apoptotic Cell Death (Pmentioning
confidence: 99%
“…NLRP3 inflammasome activation has been implicated in both resistance and susceptibility in murine models of cutaneous leishmaniasis (1618). However, the role of other NLRs in leishmaniasis is unknown.…”
Section: Introductionmentioning
confidence: 99%