The NLRP3 inflammasome in viral infection (Review)

Zheng, Qinguo; Hua, Chunting; Liang, Qiao; Cheng, Hao

doi:10.3892/mmr.2023.13047

Cited by 6 publications

(5 citation statements)

References 111 publications

(137 reference statements)

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confidence: 99%

“…In recent years, many studies have been reported that many different viruses could regulated inflammasome activation by direct mechanisms (the proteins or nucleic acids of viruses could directly affect inflammasome activation) or indirect mechanisms (viruses could affect inflammasome activation by regulating other signal pathways or other proteins). Previous studies have indicated inflammasome participates in viral infections (Lupfer et al, 2015;Zheng et al, 2023). However, what roles that inflammasome plays in the infection of specific virus remain unknown.In this Research Topic, there are six articles (three original research articles and three review articles) published, focusing on the role of inflammasome in viral infection.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19) in recent years, and it could activate NLRP3 inflammasome (Pan et al, 2021).…”

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confidence: 99%

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Editorial: The role of inflammasome in viral infection

Wan,

Zhang,

Pan

et al. 2023

Front. Cell. Infect. Microbiol.

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confidence: 99%

mentioning

confidence: 99%

Editorial: The role of inflammasome in viral infection

Wan,

Zhang,

Pan

et al. 2023

Front. Cell. Infect. Microbiol.

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“…The NLRP3 inflammasome is a key player in inflammation-related diseases, consisting of NLRP3, ASC, and caspase-1, which produce proinflammatory cytokines. Targeting the NLRP3 inflammasome holds promise for controlling HSV replication and related diseases [10][11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…This overproduction is a crucial aspect of the host's innate immune response [14,15]. Therefore, the NLRP3 inflammasome is an important therapeutic target for HSV replication and HSV infection-associated diseases [16,17].…”

Section: Introductionmentioning

confidence: 99%

Korean Chestnut Honey Suppresses HSV-1 Infection by Regulating the ROS–NLRP3 Inflammasome Pathway

Kwon,

Kim,

Kim

et al. 2023

Antioxidants

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Herpes simplex virus 1 (HSV-1) is double-stranded DNA virus that belongs to the Orthoherpesviridae family. It causes serious neurological diseases of the central nervous system, such as encephalitis. The current U.S. Food and Drug Administration (FDA)-approved drugs for preventing HSV-1 infection include acyclovir (ACV) and valacyclovir; however, their long-term use causes severe side effects and often results in the emergence of drug-resistant strains. Therefore, it is important to discover new antiviral agents that are safe and effective against HSV-1 infection. Korean chestnut honey (KCH) has various pharmacological activities, such as antioxidant, antibacterial, and anti-inflammation effects; however, antiviral effects against HSV-1 have not yet been reported. Therefore, we determined the antiviral activity and mechanism of action of KCH after HSV-1 infection on the cellular level. KCH inhibited the HSV-1 infection of host cells through binding and virucidal steps. KCH decreased the production of reactive oxygen species (ROS) and calcium (Ca2+) following HSV-1 infection and suppressed the production of inflammatory cytokines by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) activity. Furthermore, we found that KCH inhibited the expression of the nod-like receptor protein 3 (NLRP3) inflammasome during HSV-1 infection. Taken together, the antiviral effects of KCH occur through multiple targets, including the inhibition of viral replication and the ROS-mediated NLRP3 inflammasome pathway. Our findings suggest that KCH has potential for the treatment of HSV-1 infection and related diseases.

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“…Among the inflammasomes responding to RNA viruses, the NLRP3 inflammasome is the best characterized [52]. NLRP3 activation is triggered in response to microbial infection via PAMPs or upon host cell damage, through damage-associated molecular patterns (DAMPs) signaling [53]. The NLRP3 inflammasome is composed of the NLRP3 receptor, the apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC) adaptor molecule and caspase-1 [54].…”

Section: Recognition Of Sars-cov-2 By Nlrsmentioning

confidence: 99%

SARS-CoV-2: A Glance at the Innate Immune Response Elicited by Infection and Vaccination

Manfrini,

Notarbartolo,

Grifantini

et al. 2024

Antibodies

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The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to almost seven million deaths worldwide. SARS-CoV-2 causes infection through respiratory transmission and can occur either without any symptoms or with clinical manifestations which can be mild, severe or, in some cases, even fatal. Innate immunity provides the initial defense against the virus by sensing pathogen-associated molecular patterns and triggering signaling pathways that activate the antiviral and inflammatory responses, which limit viral replication and help the identification and removal of infected cells. However, temporally dysregulated and excessive activation of the innate immune response is deleterious for the host and associates with severe COVID-19. In addition to its defensive role, innate immunity is pivotal in priming the adaptive immune response and polarizing its effector function. This capacity is relevant in the context of both SARS-CoV-2 natural infection and COVID-19 vaccination. Here, we provide an overview of the current knowledge of the innate immune responses to SARS-CoV-2 infection and vaccination.

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The NLRP3 inflammasome in viral infection (Review)

Cited by 6 publications

References 111 publications

Editorial: The role of inflammasome in viral infection

Editorial: The role of inflammasome in viral infection

Korean Chestnut Honey Suppresses HSV-1 Infection by Regulating the ROS–NLRP3 Inflammasome Pathway

SARS-CoV-2: A Glance at the Innate Immune Response Elicited by Infection and Vaccination

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