The nobel prize in physiology or medicine — 2021

Hagymási, Krisztina

doi:10.1007/s11224-022-01890-7

Struct Chem

2022

DOI: 10.1007/s11224-022-01890-7

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The nobel prize in physiology or medicine — 2021

Krisztina Hagymási

Abstract: The Nobel Assembly at Karolinska Institutet awarded the 2021 Nobel Prize in Physiology and Medicine jointly to David Julius and Ardem Patapoutian for their discoveries of receptors for temperature and touch. TRP and Piezo channels also have several additional physiological functions, so targeting their functions could be a promising therapeutic target for different diseases, including the management of pain.

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David Julius and Ardem Patapoutian: Pioneers in Sensory Biology and Neuroscience

Rukadikar,

Charulata,

Dipankar

et al. 2024

Cureus

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Sensory biology is a critical area within neuroscience, exploring how organisms respond to environmental stimuli such as temperature, pain, and mechanical forces. David Julius and Ardem Patapoutian have made landmark contributions to this field by identifying crucial receptors. Julius's discovery of transient receptor potential (TRP) channels, including transient receptor potential cation channel subfamily V member 1 (TRPV1), which detects heat and pain, revolutionized sensory biology and opened new paths for pain management. Similarly, Patapoutian's identification of Piezo channels, which respond to mechanical stimuli like touch and pressure, has deepened our understanding of sensory perception. Their combined work has not only advanced scientific knowledge but also introduced potential treatments for chronic pain and sensory disorders. This paper reviews their contributions and the broader implications for sensory biology and therapeutic developments.

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David Julius and Ardem Patapoutian: Pioneers in Sensory Biology and Neuroscience

Rukadikar,

Charulata,

Dipankar

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

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The nobel prize in physiology or medicine — 2021

Cited by 1 publication

References 8 publications

David Julius and Ardem Patapoutian: Pioneers in Sensory Biology and Neuroscience

David Julius and Ardem Patapoutian: Pioneers in Sensory Biology and Neuroscience

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