The Nogent Institute - 50 Years of Embryology

Douarin, Nicole M. Le

doi:10.1387/ijdb.041952nl

Cited by 15 publications

(9 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding greatly motivated the fate mapping of various tissues by quail‐chick chimera analysis, achieved by micro‐scale tissue transplantation between these two embryos under a binocular microscope. Quail‐chick chimera analysis has allowed the acquisition of many fundamental ideas and concepts in immunology, hematology, neurobiology, and developmental biology (for reviews, see Le Douarin ; Le Douarin et al . ).…”

Section: Overview Of the Avian Model In Vascular Biologymentioning

confidence: 99%

Dorsal aorta formation: Separate origins, lateral‐to‐medial migration, and remodeling

Sato

2012

Dev Growth Differ

View full text Add to dashboard Cite

Blood vessel formation is a highly dynamic tissue-remodeling event that can be observed from early development in vertebrate embryos. Dorsal aortae, the first functional intra-embryonic blood vessels, arise as two separate bilateral vessels in the trunk and undergo lateral-to-medial translocation, eventually fusing into a single large vessel at the midline. After this dramatic remodeling, the dorsal aorta generates hematopoietic stem cells. The dorsal aorta is a good model to use to increase our understanding of the mechanisms controlling the establishment and remodeling of larger blood vessels in vivo. Because of the easy accessibility to the developing circulatory system, quail and chick embryos have been widely used for studies on blood vessel formation. In particular, the mapping of endothelial cell origins has been performed using quail-chick chimera analysis, revealing endothelial, vascular smooth muscle, and hematopoietic cell progenitors of the dorsal aorta. The avian embryo model also allows conditional gene activation/inactivation and direct observation of cell behaviors during dorsal aorta formation. This allows a better understanding of the molecular mechanisms underlying specific morphogenetic events during dynamic dorsal aorta formation from a cell behavior perspective.

show abstract

Section: Overview Of the Avian Model In Vascular Biologymentioning

confidence: 99%

Dorsal aorta formation: Separate origins, lateral‐to‐medial migration, and remodeling

Sato

2012

Dev Growth Differ

View full text Add to dashboard Cite

show abstract

“…As a side consequence of this study, Nicole Le Douarin became interested in the neural crest (having associated the liver endoderm to mesonephritic mesenchyme, she found that medulloadrenal cells differentiated in the combination) (see Le Douarin, 2005 in this issue). This transitory structure, evolution's innovation in vertebrates, became and still is one of Le Douarin's main themes of investigation.…”

Section: In This Issuementioning

confidence: 94%

L'cole de Nogent: the contributions of Etienne Wolff and Nicole Le Douarin

Galperin

2005

Int. J. Dev. Biol.

View full text Add to dashboard Cite

We retrace here the foundation of the "Nogent School". What were its main scientific orientations? Two fields of research dominated Etienne Wolff's work: Experimental Teratology and Intersexuality. Nicole Le Douarin's work , in one sense, started with a remarkable tool which is the quail / chick marker system. She applied this system to the study of in vivo migration of cells during embryonic life, i.e.neural crest cells and lymphoid progenitors. This article revisits some of these fundamental aspects.

show abstract

“…Biol. Special Issue dedicated to the Nogent Institute, Le Douarin, 2005) and the permeability between the discovery of VEGFR-2 (Eichmann et al, 1997) and the application of this discovery to the demonstration that endothelial cells in the aorta were able to convert into hematopoietic cells.…”

Section: When Did Your Interest In Developmental Hematopoiesis Start?mentioning

confidence: 99%

Developmental hematopoiesis: historical background and perspectives. An interview with Nicole Le Douarin

Durand¹,

Jaffredo²

2010

Int. J. Dev. Biol.

View full text Add to dashboard Cite

Nicole le Douarin has shown a long lasting interest for developmental hematopoiesis. Starting from her early research experience, we travel along the main discoveries and concepts that have shaped the modern view of developmental hematopoiesis. All through, we survey the seminal contribution of the "Ecole de Nogent" about lymphocyte homing and the discovery of endothelial-specific tyrosine kinases. This interview is a promenade through the past and present of developmental hematopoiesis narrated by an exceptional personality and an outstanding scientist.

show abstract

The Nogent Institute - 50 Years of Embryology

Cited by 15 publications

References 97 publications

Dorsal aorta formation: Separate origins, lateral‐to‐medial migration, and remodeling

Dorsal aorta formation: Separate origins, lateral‐to‐medial migration, and remodeling

L'cole de Nogent: the contributions of Etienne Wolff and Nicole Le Douarin

Developmental hematopoiesis: historical background and perspectives. An interview with Nicole Le Douarin

Contact Info

Product

Resources

About