The non-ambulatory model in dog multidose infusion toxicity studies

Pickersgill, Nigel; Burnett, Roger M.

doi:10.1201/9781482268133-12

Cited by 1 publication

(3 citation statements)

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“…These are possibly a reaction to the suture material used for securing the catheter. Sutures can also cause some reduction in the blood flow, thus promoting thrombus formation (Pickersgill and Burnett, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Combined incidences of these areas for both sexes was far lower than the incidence of thromboemboli. This may appear surprising in view of the level of thromboemboli, but the extent of damage in the lungs depends on the size of the vessel and is limited by collateral circulation (Pickersgill and Burnett, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…The principal advantage of continuous intravenous infusion as a route of administration is the ability to maintain a relatively constant blood level of the drug. Over the last decade there has been increasing interest in the development of drugs for continuous intravenous administration, associated with advances in the number and type of techniques that allow their toxicological evaluation (Pickersgill and Burnett, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Common Vascular Changes in the Jugular Vein of Saline Controls in Continuous Infusion Studies in the Beagle Dog

Lilbert¹,

Mowat²

2004

Toxicol Pathol

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This review was performed to assess the nature and incidence of procedure-related background changes in control dogs receiving saline by continuous infusion, and to compare them with data from a similar review previously done in Cynomolgus monkeys. Data were collected from 14 dog studies performed over an 8-year period (i.e., 86 animals in total). The review was restricted to lesions at the injection site, in the lungs and at the catheter's entry point. The most frequently seen changes were endothelial hyperplasia (67.4%) and intimal thickening at the injection site (80.2%) and interstitial pneumonitis in the lungs (52.6%), all seen at a higher incidence in dogs than in primates. Although incidences of thrombosis at the injection site were similar in both dogs (27.9%) and monkeys (34.1%), the incidences of thromboemboli and secondary infarction in the lungs were much higher in dogs. This suggests that dogs have a greater propensity to thrombus formation and fragmentation at the injection site. However the fact that the femoral vein is used in monkeys and the jugular vein in dogs may explain this difference. The larger diameter of the jugular vein in the dog with its greater turbulence of blood flow possibly predisposes to fragmentation and dispersal of thrombi.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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