The Non-Enzymatic Antioxidant and Level of Oxidative Stress of Tuberculosis Patients in Selected Treatment Center in Addis Ababa Ethiopia

Gebretsadik, Gebrehiwot; Seifu, Daniel; Yimer, Getnet; Menon, M.K.

doi:10.4236/jtr.2015.33010

Cited by 12 publications

(8 citation statements)

References 26 publications

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“…[ 11 ]. According to Ethiopian studies, the magnitude of undernutrition in this study was still lower than in studies conducted in Ambo, West Ethiopia (63.5 percent) [ 14 ], Metema (51 percent) [ 15 ], and Gamo Goffa Zone, South Ethiopia (50 percent) [ 19 ] but higher than in studies conducted in Addis Ababa, Ethiopia (27.15 percent) [ 17 ]. The difference may be explained by differences in the socioeconomic status, study area, lifestyle, feeding pattern and economic status of the countries, and sample size of the study.…”

Section: Discussioncontrasting

confidence: 55%

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Determinants of Undernutrition among Adult Tuberculosis Patients Receiving Treatment in Public Health Institutions in Shashemane Town, Southern Ethiopia

Tesfaye

Egeta

Mesfin

et al. 2021

Journal of Nutrition and Metabolism

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Background. Undernutrition and tuberculosis are the major concerns of underdeveloped regions of the world. Tuberculosis makes undernutrition worse and undernutrition weakens immunity, thereby increasing the likelihood that latent tuberculosis will develop into active disease. Nevertheless, little has been understood about undernutrition among patients with infectious disease like tuberculosis in Ethiopia. This study was conducted to determine the magnitude of undernutrition and its determinants among tuberculosis patients in Shashemane public health institutions, Southern Ethiopia. Methods. An institution-based cross-sectional study was conducted in two public hospitals and ten health centers of Shashemane Town from March 12, to April 12, 2017, among 368 adult tuberculosis patients on treatment follow-up. Sociodemographic and socioeconomic characteristics and anthropometric data were collected. Data were entered into EpiData version 3.3 computer software and analyzed using SPSS version 20. Bivariable logistic regression analyses were done to assess the association between outcome variable at bivariate analysis, and multivariable logistic regression model was used to assess factors that were independently associated with undernutrition. Odds ratios along with 95% confidence interval (CI) were estimated to measure the strength of the association, and level of statistical significance was declared at P value ≤0.05. Result. The overall magnitude of undernutrition among adult tuberculosis patients in this study was 28.8% (95% CI = 0.25–0.34). Patients in the age group of forty-five and above ((AOR = 3.39, 95% CI = (1.6–7.18)), residents in rural area ((AOR = 1.95, 95% CI = (1.07–3.54)), those with problem with eating ((AOR = 2.361, 95% CI = (1.332–4.185)), and those who are not on food supplementation ((AOR = 2.21, 95% CI = (1.06–4.58)) were significantly at higher risk of undernutrition. Conclusion. The magnitude of undernutrition in the study setting was found to be significantly higher. Age greater than forty-five, living in rural area, and lack of nutritional care and support were identified as the factors associated with undernutrition. Thus, relevant actors should give attention to fast nutritional intervention together with standard therapeutic regimen in the management of pulmonary tuberculosis patients to curb their nutritional derangement.

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Section: Discussioncontrasting

confidence: 55%

“…Few studies revealed that the magnitude of undernutrition among TB patients ranged from 52 to 90% in lowincome countries other than SSA countries [6][7][8][9], 43-78% in SSA [10][11][12][13] and 27.2% to 84.4%, [14][15][16][17][18][19] in Ethiopia.…”

Section: Introductionmentioning

confidence: 99%

Determinants of Undernutrition among Adult Tuberculosis Patients Receiving Treatment in Public Health Institutions in Shashemane Town, Southern Ethiopia

Tesfaye

Egeta

Mesfin

et al. 2021

Journal of Nutrition and Metabolism

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“…If the levels of free radicals and ROS exceed the reduction level of the antioxidant system, the antioxidant capacity of the body decreases, resulting in oxidative damage to biological macromolecules [39]. A large number of studies have shown that free radicals can cause peroxidative damage to cell membrane lipids and produce MDA which involved in attacking polyunsaturated fatty acids in biological cell membranes, further triggering lipid peroxidation, leading to more severe oxidative stress damage [40,41]. However, many studies have shown that probiotics have excellent antioxidant functions.…”

Section: Discussionmentioning

confidence: 99%

Effects of probiotic BaSC06 on intestinal digestion and absorption function, antioxidant capacity and macrophage polarization and microbiota composition in fattening pigs

Cao¹,

Tang²,

Zeng³

et al. 2020

Preprint

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Background: The previous study in our team found that supplementation of probiotic Bacillus amyloliquefaciens SC06 (BaSC06) as an alternative to antibiotics (Kitasamycin) can effectively reduce the diarrhea rate and promote the growth performance of weaned piglets. We speculate that BaSC06 may become a better substitute for antibiotics for fattening pigs. Hence, the objective of the present study is to evaluate the effects of BaSC06 substitute antibiotics on growth performance, digestive functions, antioxidant capacity, macrophage polarization and intestinal microbiota of fattening pigs. Methods: A total of 117 fattening pigs with similar weight and genetic basis were selected and divided into three groups: Anti group, fed with basal diet supplemented with 40 g/t Kitasamycin; Anti + Ba group, fed with 1 × 108 CFU/kg BaSC06 and 20 g/t Kitasamycin; Ba group, fed with 1 × 108 CFU/kg BaSC06 replaced Kitasamycin. Each treatment had three replications of 13 pigs per pen. Results: It indicated that BaSC06 replacement significantly improved ADFI and ADG in fattening pigs. It also improved intestinal digestion and absorption function with the increased activities of intestinal digestive enzymes and higher expression of glucose transporters SGLT1 and small peptide transporters PEPT1, maintained intestinal integrity significantly. Besides, supplementation with BaSC06 enhanced intestinal and body antioxidant capacity by activating Nrf2/ Keap1 antioxidant signaling pathway. In addition, BaSC06 as a substitute could alleviate intestinal inflammation by inhibiting the production of pro-inflammatory cytokines and chemokine and simultaneously increase the expression of M1 and M2 macrophage marker proteins in the intestinal mucosa. The transcription factor STAT3 regulated M2 polarization, which maintained immune homeostasis and reduced inflammation. What’s more, BaSC06 could improve the composition of the microbiota as well by increasing the proportion of Firmicutes, and reducing the proportion of Bacteroidetes and Proteobacteria. Conclusions: Taken together, our findings indicated that diet supplementation with BaSC06 instead of antibiotics increased the growth performance of piglets by improving the digestion and absorption of nutrients, intestinal microbiota composition and mucosal structure, antioxidative capacity and immune functions (including increasing M1and M2 polarization of macrophage).

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“…This group of fat soluble antioxidants has been shown to benefit respiratory health due to their ability to scavenge reactive oxygen species "ROS" and reduce oxidative stress (11). Vitamin C is the major water soluble antioxidant and a powerful inhibitor of lipid peroxidation and regenerates vitamin E in lipoproteins and membranes (12).…”

Section: Original Articlementioning

confidence: 99%

Role of oxidative stress and outcome of various surgical approaches among patients with bullous lung disease candidate for surgical interference

et al. 2016

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The Non-Enzymatic Antioxidant and Level of Oxidative Stress of Tuberculosis Patients in Selected Treatment Center in Addis Ababa Ethiopia

Abstract: G. Gebretsadik et al. 64volunteers. In contrast to this, the MDA value was significantly higher both in the newly diagnosed TB patients and TB patients who completed treatment than in healthy volunteers suggesting higher degree of oxidative stress.

Cited by 12 publications

References 26 publications

Determinants of Undernutrition among Adult Tuberculosis Patients Receiving Treatment in Public Health Institutions in Shashemane Town, Southern Ethiopia

Determinants of Undernutrition among Adult Tuberculosis Patients Receiving Treatment in Public Health Institutions in Shashemane Town, Southern Ethiopia

Effects of probiotic BaSC06 on intestinal digestion and absorption function, antioxidant capacity and macrophage polarization and microbiota composition in fattening pigs

Role of oxidative stress and outcome of various surgical approaches among patients with bullous lung disease candidate for surgical interference

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