The baryon-acoustic oscillation (BAO) feature in the Lyman-α forest is a key probe of the cosmic expansion rate at redshifts z ∼ 2.5, well before dark energy is believed to have become significant. A key advantage of the BAO as a standard ruler is that it is a sharp feature and hence is more robust against broadband systematic effects than other cosmological probes. However, if the Lyman-α forest transmission is sensitive to the initial streaming velocity of the baryons relative to the dark matter, then the BAO peak position can be shifted. Here we investigate this sensitivity using a suite of hydrodynamic simulations of small regions of the intergalactic medium with a range of box sizes and physics assumptions; each simulation starts from initial conditions at the kinematic decoupling era (z ∼ 1059), undergoes a discrete change from neutral gas to ionized gas thermal evolution at reionization (z ∼ 8), and is finally processed into a Lyman-α forest transmitted flux cube. Streaming velocities suppress smallscale structure, leading to less violent relaxation after reionization. The changes in the gas distribution and temperature-density relation at low redshift are more subtle, due to the convergent temperature evolution in the ionized phase. The change in the BAO scale is estimated to be of the order of 0.12% at z = 2.5; some of the major uncertainties and avenues for future improvement are discussed. The predicted streaming velocity shift would be a subdominant but not negligible effect (of order 0.26σ) for the upcoming DESI Lyman-α forest survey, and exceeds the cosmic variance floor.