The nonbilharzial urothelial carcinoma in Egypt

El-Bolkainy, Nabil; El-Bolkainy, Tarek; Mandour, Esam M.; Badawy, Omnia M.; Abdelbaky, Heba; Elattar, Inas

doi:10.1097/01.xej.0000534713.68027.91

Cited by 5 publications

(7 citation statements)

References 19 publications

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“…This is similar to an earlier Egyptian publication where the rectum constituted 27%. [ 52 ] Conversely, in a study by Eisa, rectal carcinoma constituted 42.7%. [ 51 ]…”

Section: Discussionmentioning

confidence: 99%

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Validity and clinical impact of glucose transporter 1 expression in colorectal cancer

GabAllah¹,

Habib²,

Soliman³

et al. 2017

Saudi J Gastroenterol

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Background/Aim:There is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements, prognosis still remains an irritating question with no definite answer. Being a fundamental player in cancer metabolism, glucose transporter 1 (GLUT1) could be utilized as a prognostic biomarker that could fuel development of new treatment strategies. The aim of this study was to assess the validity of GLUT1 expression as a prognostic biomarker and to elucidate to what extent it is immersed in poor clinical outcome among CRC patients.Patients and Methods:GLUT1 expression in peripheral blood specimens was analyzed by quantitative real-time polymerase chain reaction in 47 CRC patients and 20 healthy controls.Results:There was significantly elevated GLUT1 expression in peripheral blood of CRC patients than in controls (P < 0.001). The cutoff value of 0.605 provided 98% sensitivity and 100% specificity. There were significantly higher values of GLUT1 expression in patients under 50 years (P = 0.003), performance status 2 (P = 0.009), stage IV (P < 0.001), and presence of metastasis (P < 0.001). GLUT1 expression showed nonsignificant association with overall survival (P = 0.068), while tumor stage (P = 0.01) and metastasis (P = 0.009) were significantly associated with lower overall survival.Conclusion:GLUT1 is sensitive and specific marker for CRC. It is overexpressed in young age patients, poor performance status, and stage IV patients. Although this was not statistically significant, GLUT 1 showed higher expression level in patients with lesser survival.

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“…This is similar to an earlier Egyptian publication where the rectum constituted 27%. [ 52 ] Conversely, in a study by Eisa, rectal carcinoma constituted 42.7%. [ 51 ]…”

Section: Discussionmentioning

confidence: 99%

“…According to National Cancer Institute Cairo records, it is more common in males, and the median age in Egyptian patients is about 50 years. [ 6 ] Identification of prognostic biomarkers that could fuel development of new treatment strategies would be of a particular clinical relevance. [ 7 8 ]…”

Section: Introductionmentioning

confidence: 99%

Validity and clinical impact of glucose transporter 1 expression in colorectal cancer

GabAllah¹,

Habib²,

Soliman³

et al. 2017

Saudi J Gastroenterol

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“…Egyptian males have the highest mortality rates (16.3 per 100,000) worldwide, which is twice as high as the highest rates in Europe and over 4 times higher than that in the United States 4 & 3 .…”

Section: Introductionmentioning

confidence: 95%

Significance of D2-40 and CXCL5 Expression in Urinary Bladder Transitional Cell Carcinoma: An Immunohistochemical Study

Abdalla

Elbalshy

Zafer

et al. 2021

Benha Medical Journal

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Background: Transitional cell carcinoma remains a challenge in the oncology field, representing an ideal candidate for research on biomarkers that could identify patient's progression and prognosis. D2-40 and CXCL5 have been implicated in progression of many cancers, but their significance in urinary bladder TCC remains unclear. The aim of this study is to assess their possible significance in urinary bladder transitional cell carcinoma. Methods:Immunohistochemistry was performed to examine the expression of D2-40 and CXCL5 in 50 cases of urinary bladder TCC and 10 cases of normal urothelium taken as a normal control. Statistical analysis methods were used to evaluate the relationship between D2-40 and CXCL5 and various clinicopathological parameters. Results: D2-40 was expressed in the lymphatic endothelial cytoplasm of all cases high lightening the tumor emboli in cancer lymphatic vessels. CXCL5 was found to be expressed in all urinary bladder TCC cases but not in normal control. The two markers significantly correlated with associated necrosis, tumor grade, T stage, N stage and presence of H&E detected LVI. CXCL5 was also positively correlated with presence of associated necrosis and CIS while D2-40 was insignificantly correlated with both. D2-40 detected intralymphatic tumor emboli are associated with lymph node metastasis in a highly significant correlation. Conclusions: The results suggested that CXCL5 might be involved in urinary bladder TCC carcinogenesis. It could be concluded that D2-40 and CXCL5 may have a possible role in urinary bladder TCC progression and prognosis. D2-40 might be considered as a more reliable method in predicting tumor spread and lymph node metastasis.

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“…According to the National Cancer Institute, bladder cancer ranks third among all malignancies in Egypt for both sexes, accounting for 6.9% of all cancer cases (3) .…”

Section: Introductionmentioning

confidence: 99%

Studying The Expression of RNA-Binding Proteins RBM-Hur, and Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) in Urothelial Carcinoma; Immunohistochemical Study

Abdelrahman¹,

Elkheir²,

ElAttar³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: In developed nations, bladder cancer is a main cause of mortality. Urothelial bladder cancer (UBC) makes up the bulk of cases up to (90%) . An important lipid metabolism enzyme called LPCAT1 has been linked to the development of various cancers. HuR is an RNA-binding protein involved in tumor growth, regulates normal cell proliferation and inflammatory responses associated with cancer (13). that regulates the healthy cell proliferation and inflammatory responses associated with cancer. The study aimed to evaluate the significance expression of RBM-HuR and LPCAT1 in UBC. Methods: The current retrospective study included 50 formalin-fixed, paraffin-embedded blocks for UBC. to examine the expression of both RBM-HuR and LPCAT in UBC was performed using Immunohistochemistry where. anti RBM-HuR and anti LPCAT1 immunostaining were performed using Avidin-Biotin complex technique and correlated to clinicopathological parameters including pT stage and grade of the tumor, lymph node (LN) metastasis, distant metastasis, lympho-vascular invasion, and associated CIS Results: LPCAT1 expression was negatively correlated with the ( pT stage and grade of the tumor, lymph node (LN) metastasis, distant metastasis, lympho-vascular invasion, and associated CIS) (P < 0.05). However, RBM-HuR expression was positively correlated to the same clinicopathological criteria. (P< 0.05). Conclusions: RBM-HuR and LPCAT1 could both be used as potential prognostic indicators in UBC.

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The nonbilharzial urothelial carcinoma in Egypt

Cited by 5 publications

References 19 publications

Validity and clinical impact of glucose transporter 1 expression in colorectal cancer

Validity and clinical impact of glucose transporter 1 expression in colorectal cancer

Significance of D2-40 and CXCL5 Expression in Urinary Bladder Transitional Cell Carcinoma: An Immunohistochemical Study

Studying The Expression of RNA-Binding Proteins RBM-Hur, and Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) in Urothelial Carcinoma; Immunohistochemical Study

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