Magnetic reconnection and plasma turbulence are ubiquitous and key processes in the Universe. These two processes are suggested to be intrinsically related: magnetic reconnection can develop turbulence, and, in turn, turbulence can influence or excite magnetic reconnection. In this study, we report a rare and unique electron diffusion region (EDR) observed by the Magnetospheric Multiscale mission in the Earth’s magnetotail with significantly enhanced energetic particle fluxes. The EDR is in a region of strong turbulence within which the plasma density is dramatically depleted. We present three salient features. (1) Despite the turbulence, the EDR behaves nearly the same as that in 2D quasi-planar reconnection; the observations suggest that magnetic reconnection continues for several minutes. (2) The observed reconnection electric field and inferred energy transport are exceptionally large. However, the aspect ratio of the EDR (one definition of reconnection rate) is fairly typical. Instead, extraordinarily large-amplitude Hall electric fields appear to enable the strong energy transport. (3) We hypothesize that the high-energy transport rate, density depletion, and the strong particle acceleration are related to a near-runaway effect, which is due to the combination of low-plasma-density inflow (from lobes) and possible positive feedback between turbulence and reconnection. The detailed study on this EDR gives insight into the interplay between reconnection and turbulence, and the possible near-runaway effect, which may play an important role in other particle acceleration in astrophysical plasma.