2015
DOI: 10.1016/j.neuroscience.2015.05.030
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The nonsteroidal antiinflammatory drug piroxicam reverses the onset of depressive-like behavior in 6-OHDA animal model of Parkinson’s disease

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Cited by 30 publications
(13 citation statements)
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“…The major inhibitor effect of aspirin on NMSC and precursors is related to its targeting elevated COX-2 levels in SCC. Most studies also examined the use of PXM in different disorders, especially for analyzing absorbance, tolerance, and efficacy in animal models, 35 – 37 but the efficacy of PXM in humans was analyzed considering the general effects of NSAIDs, as in colon rectal carcinoma 38 , 39 or in NMSC. 40 42 …”
Section: Pxm Effects For the Prevention Of Nmscmentioning
confidence: 99%
“…The major inhibitor effect of aspirin on NMSC and precursors is related to its targeting elevated COX-2 levels in SCC. Most studies also examined the use of PXM in different disorders, especially for analyzing absorbance, tolerance, and efficacy in animal models, 35 – 37 but the efficacy of PXM in humans was analyzed considering the general effects of NSAIDs, as in colon rectal carcinoma 38 , 39 or in NMSC. 40 42 …”
Section: Pxm Effects For the Prevention Of Nmscmentioning
confidence: 99%
“…tis, osteoarthrosis, and general skeletal disorders. [28,29] It exhibits low solubility in water and there are only af ew side effects related to its direct incorporation, which could limit its passage into the systemic circulation. These characteristics make PX an interesting active compound for use in new delivery systems, such as NLCs.…”
Section: Introductionmentioning
confidence: 99%
“…However, there are several secondary effects related to the use of NSAIDs, with gastric irritation being the most common . Among these drugs, piroxicam (PX) (Scheme ) has great pharmacological and therapeutic potential, and is quite efficient in the treatment of rheumatoid arthritis, osteoarthrosis, and general skeletal disorders . It exhibits low solubility in water and there are only a few side effects related to its direct incorporation, which could limit its passage into the systemic circulation.…”
Section: Introductionmentioning
confidence: 99%
“…We simply aimed here to investigate any baseline redox/inflammatory peculiarity concerning the long-term supplementation with ( n -3)/PUFAs and/or astaxanthin in motor control brain regions. Definitely, more answers regarding the efficiency of antioxidant therapies provided by marine nutraceuticals should come out by reproducing the experiments here in well-established neurodegenerative animal models, such as Alzheimer’s and Parkinson’s diseases [ 32 , 33 ] or age-related sarcopenia models [ 34 ]. All these neurodegenerative processes are marked by alterations in the free radical metabolism and accumulation of oxidized products and/or oxylipid adducts during disease progression in humans and animals [ 35 ].…”
Section: Discussionmentioning
confidence: 99%