The nontoxic mushroom Auricularia auricula contains a polysaccharide with anticoagulant activity mediated by antithrombin

Yoon, San-Hyun; Yu, Miao; Pyun, Yu‐Ryang; Hwang, Jae Kwan; Chu, Djong Chi; Juneja, Lekh Raj; Mourāo, Paulo A.S.

doi:10.1016/j.thromres.2003.10.022

Cited by 131 publications

(75 citation statements)

References 26 publications

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“…The sources of these bioactive compounds include fruiting body, mycelia, cultivation broth, submerged cultivation mycelia and fermentation derivatives (Cheung, 1996;Fiore & Kakkar, 2003;Kwok et al, 2005;Sugimoto et al, 2007;Wang et al, 1995;Wong et al, 2011;Wu et al, 2010, Yamamoto et al, 2005Yoon et al, 2003). This chapter focuses on the fibrinolytic enzymes derived from medicinal mushrooms.…”

Section: Bioactive Compounds In Mushroomsmentioning

confidence: 99%

Fibrinolytic Enzymes from Medicinal Mushrooms

Lu¹,

Chen²

2012

Protein Structure

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Section: Bioactive Compounds In Mushroomsmentioning

confidence: 99%

Fibrinolytic Enzymes from Medicinal Mushrooms

Lu¹,

Chen²

2012

Protein Structure

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“…In recent years, A. auricula was reported to have many biological activities, including anticoagulant activity (Yoon et al 2003), antitumor activity (Mizuno et al 1995), hypoglycemia (Takeuchi et al 2004) and hypocholesterolemia (Cheung 1996). Up to now, considerable attention of A. auricula has been focused on dietary fiber and polysaccharide components, mainly extracted from its fruiting body.…”

Section: Introductionmentioning

confidence: 99%

Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet

Gang

Luo

et al. 2010

J Food Sci Technol

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The cholesterol-lowering properties of Auricularia auricula are commonly attributed to the presence of polysaccharides based on previous research. The present study was designed to investigate the effects of ethanol extract of A. auricula (AAE) on hypercholesterolemia in ICR mice. AAE contained more than 16% (g/g) polyphenolic compounds, excluding other interfering factors such as polysaccharides, water-soluble fibre and protein. Thirtysix mice were randomly assigned to three groups (n=12). The experimental group was fed cholesterol-enriched diet (CED) with oral administration of AAE (150 mg/kg/d b.w.) for 8-week, normal control group and CED control group received either a regular diet (RD) or CED along with oral administration of equal volume distilled water. Serum lipid profiles and antioxidant status were measured in addition to fecal neutral cholesterol and bile acids. AAE showed a remarkable hypocholesterolemic effect, improving antioxidant status, decreasing the level of total cholesterol and atherosclerosis index, increasing the level of high-density lipoprotein cholesterol and fecal excretion of bile acids. No apparent effects on serum triglycerides, low-density lipoprotein cholesterol, fecal excretion of neutral cholesterol and feeding efficiency were observed among all groups. These results indicated that A. auricula functional components, which prevented hypercholesterolemia contained polyphenolic compounds, in addition to polysaccharides.

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“…Polysaccharides are common structural and storage polymers in living organisms. Polysaccharides are potentially useful, and are biologically active ingredients for pharmaceutical uses due to a variety of biological activities, such as immunological, anti-radiation, anti-blood coagulation, anti-cancer, anti-human immunodeficiency virus (HIV) and hypoglycemic activities (Yoon et al, 2003;Yang et al, 2005). The activity of polysaccharides is closely related to their structurerelated aspects such as molecular mass, degree of substitution, degree of branching, sugar component and the structure of main chain and branches (Bohn and BeMiller, 1995).…”

Section: Introductionmentioning

confidence: 99%

Extraction, characterization and its antioxidant efficacy of polysaccharides from Sepia aculeata (Orbigny, 1848) cuttlebone

Subhapradha¹,

Ramasamy²,

Seedevi³

et al. 2014

Afr. J. Biotechnol.

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Ocean is the source of large group of structurally unique natural products that are mainly found in invertebrates such as sponges, tunicates, bryozoans and mollusks. In the present study, polysaccharide was extracted from the cuttlebone of Sepia aculeata and the structure was determined through Fourier transform infra red spectroscopy. Then, the antioxidant efficacy was evaluated through various antioxidant assays such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay, hydroxyl radical scavenging assay, superoxide radical scavenging assay and chelating ability on ferrous ions. The total sugar content of S. aculeata polysaccharides was 86.2%. The polysaccharide shows good antioxidant activity when compared with standard commercial antioxidants butylated hydroxyanisole (BHA) and ascorbic acid. The DPPH, superoxide and hydroxyl radical scavenging effect of polysaccharides was found to be 36.27% at 10 mg/ml, 59.57% at 0.5 mg/ml and 45.86% at 3.2 mg/ml, respectively. The chelating effect of polysaccharides was 48.61% at 10 mg/ml.

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The nontoxic mushroom Auricularia auricula contains a polysaccharide with anticoagulant activity mediated by antithrombin

Cited by 131 publications

References 26 publications

Fibrinolytic Enzymes from Medicinal Mushrooms

Fibrinolytic Enzymes from Medicinal Mushrooms

Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet

Extraction, characterization and its antioxidant efficacy of polysaccharides from Sepia aculeata (Orbigny, 1848) cuttlebone

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