The Normal Levels of 17-Hydroxycorticosteroids in the Peripheral Blood of Man 1

Bliss, Eugene L.; Sandberg, Avery A.; Nelson, Don H.; Eik-Nes, K

doi:10.1172/jci102798

Cited by 162 publications

(43 citation statements)

References 8 publications

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“…begun may reflect the normal fall in ACTH and cortisol secretory activity which follows the early morning peak levels (16)(17)(18). However, the subsequent increase in plasma corticoid concentration at a time (9:30 a.m. to 11:30 a.m.) when the diurnal rhythm of adrenal cortical secretory activity should have produced either a continued reduction or episodic increments in plasma corticoid concentration of smaller magnitude (19) suggests that ACTH secretion was being stimulated during the studies and that a reduction in ACTH effect on aldosterone production was not the basis for the sustained reduction in plasma aldosterone concentration.…”

Section: Resultsmentioning

confidence: 99%

Modulation of Plasma Aldosterone Concentration by Plasma Potassium in Anephric Man in the Absence of a Change in Potassium Balance

Cooke¹,

Horvath²,

Moore³

et al. 1973

J. Clin. Invest.

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A B S T R A C T In studies on seven anephric patients, glucose and insulin administration before hemodialysis produced a significant reduction in plasma potassium concentration (mean reduction = 1.3, 1.7, and 1.4 meq/ liter at 60, 120, and 180 min, respectively) which was accompanied by a significant and sustained reduction in plasma aldosterone concentration. There was a significant correlation between plasma aldosterone and plasma potassium concentration (r = +0.74, P < 0.001) and between changes in the concentration of plasma aldosterone occurring in individual patients and the corresponding changes in plasma potassium concentration (r = +0.52, P < 0.01). There was no significant change in plasma sodium concentration, and plasma corticoid concentration, which was monitored as an index of ACTH elaboration, was reduced at 60 min but increased subsequently as symptoms attributable to hypoglycemia were observed.These studies demonstrate that plasma aldosterone concentration can be modulated acutely by transitory changes in plasma potassium concentration without a change in potassium balance. The effect of glucose and insulin administration on intracellular potassium in the adrenal cortex is uncertain, and although increased net movement of potassium into cells is the presumptive mechanism of the reduction in plasma potassium concen-

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Section: Resultsmentioning

confidence: 99%

Modulation of Plasma Aldosterone Concentration by Plasma Potassium in Anephric Man in the Absence of a Change in Potassium Balance

Cooke¹,

Horvath²,

Moore³

et al. 1973

J. Clin. Invest.

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“…The dexamethasone suppressed the ACTH secretion and hence lowered the plasma and urinary values of cortisol. In the normal person the lowest levels of plasma cortisol are found between 10.00 p.m. and 2.00 a.m., then there is a gradual elevation until 4.00 a.m., followed by a steeper rise until maximum values are reached between 6.00 a.m, and 8.00 a.m.; the values then fall steadily until noon and more slowly until 10.00 p.m. where they remain approximately steady until 2.00 a.m. when the cycle starts anew (51,4). In patients 1, 2 and 4 these values were low or undetectible; in patient no.…”

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confidence: 99%

Suppression Studies in Affective Disorders

McClure

Cleghorn

1968

Canadian Psychiatric Association Journal

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“…Together with urinary procedures (5,6) these techniques have been employed to determine the secretion of cortisol by the adrenal in normal and pathological conditions (7)(8)(9) and to evaluate the factors involved in the "removal" of cortisol from the plasma in surgery (10)(11)(12)(13) and liver disease (14)(15)(16).…”

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confidence: 99%

Quantitative Determination of the Urinary Cortisolc Metabolites, “Tetrahydro F,” “Allo-Tetrahydro F” and “Tetrahydro E”: Effects of Adrenocorticotropin and Complex Trauma in the Human1

Gold¹,

Singleton²,

Macfarlane³

et al. 1958

J. Clin. Invest.

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Methods for the quantitative estimation of plasma cortisol concentration have been devised by Nelson and Samuels (1), Silber and Porter (2), and Peterson and Wyngaarden (3) who used the sulfuric acid-induced fluorescence developed by Sweat (4). Together with urinary procedures (5, 6) these techniques have been employed to determine the secretion of cortisol by the adrenal in normal and pathological conditions (7-9) and to evaluate the factors involved in the "removal" of cortisol from the plasma in surgery (10-13) and liver disease (14-16).Although a considerable amount of work has been done in isolating and identifying such urinary metabolites of cortisol as THF8 and THE (17-22) and their interconversions (23-25), much less has been done to relate the quantitative transformations of these urinary metabolites from cortisol under normal and pathological conditions. In 1953, deCourcy, Bush, Gray, and Lunnon (26) reported daily excretion values for two chromatographically separated urinary steroids corresponding in migration rates to THF and THE, in 10 1 This work was suported in part by a grant from the Atomic Energy Commission. It was sponsored and supported in part by the Subcommittee on Metabolism in Trauma, Advisory Committee on Metabolism, Office of the Surgeon General, Department of the Army, through a contract (DA-49-MD472) with Harvard University.The assistance of Winthrop Laboratories, Inc., and The Upjohn Co. is gratefully acknowledged.2 Present address: The Medical College of St. Bartholomew's Hospital, London. 3 Compounds referred to are the following: THF, tetrahydrocortisol (3a,11p,17a,21-tetrahydroxypregnan-20-one ); allo-THF (3a,1 1,l17a,21-tetrahydroxyallopregnan-20-one); THE, tetrahydrocortisone (3a,17a,21-trihydroxypregnan-11,20-dione); F, cortisol (llfi,17a,21-trihydroxypregnan-3,20-dione); E, cortisone (17a,21-dihydroxypregnan-3,11,20-trione).normal men. The mean values were 212 tg. per 24 hours for THF and 1.5 mg. per 24 hours for THE, giving a ratio for THF: THE of 0.14. Romanoff, Seelye, Rodriquez, and Pincus (27) have recently published quantitative data on the excretion of THF and THE combined with allo-THF (28, 29) in one group of normal men and in a group of schizophrenic men. There was no essential difference in the ratio of THF:(THE plus allo-THF) between the two groups of men, and the ratio was reported as approximately 1: 2. Cope and Hurlock (30) published data on the excretion of urinary THF and THE in several normal and surgical cases. Their results indicated increased excretion of these metabolites after surgery but did not show any other definite pattern of alteration of the metabolism of cortisol, although they state that "a tendency can be observed for tetrahydro-compound F excretion to rise more than does tetrahydrocortisone." In a preliminary report, Gold, Macfarlane, and Moore (31) showed that the relative proportions of the two urinary cortisol metabolites, THF and THE, were related to situations of "stress" and adrenocorticotropin (ACTH) administration. It is the purpo...

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The Normal Levels of 17-Hydroxycorticosteroids in the Peripheral Blood of Man 1

Cited by 162 publications

References 8 publications

Modulation of Plasma Aldosterone Concentration by Plasma Potassium in Anephric Man in the Absence of a Change in Potassium Balance

Modulation of Plasma Aldosterone Concentration by Plasma Potassium in Anephric Man in the Absence of a Change in Potassium Balance

Suppression Studies in Affective Disorders

Quantitative Determination of the Urinary Cortisolc Metabolites, “Tetrahydro F,” “Allo-Tetrahydro F” and “Tetrahydro E”: Effects of Adrenocorticotropin and Complex Trauma in the Human1

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