2003
DOI: 10.1053/gast.2003.50088
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The North American Study for the Treatment of Refractory Ascites

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Cited by 403 publications
(283 citation statements)
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References 23 publications
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“…9 Sinusoidal portal hypertension is clearly important in the pathogenesis of cirrhotic ascites, [1][2][3] as demonstrated by the resolution or improvement of ascites after TIPS insertion. [4][5][6][7][8] However, we believe this subtle sodium retention in these patients is not solely related to the presence of portal hypertension because the functioning TIPS normalizessinusoidal portal pressure.…”
Section: Discussionmentioning
confidence: 77%
See 1 more Smart Citation
“…9 Sinusoidal portal hypertension is clearly important in the pathogenesis of cirrhotic ascites, [1][2][3] as demonstrated by the resolution or improvement of ascites after TIPS insertion. [4][5][6][7][8] However, we believe this subtle sodium retention in these patients is not solely related to the presence of portal hypertension because the functioning TIPS normalizessinusoidal portal pressure.…”
Section: Discussionmentioning
confidence: 77%
“…However, it is clear that sinusoidal portal hypertension plays a pathogenetic role, [1][2][3] as reduction in sinusoidal portal pressure using a transjugular intrahepatic portosystemic stent shunt (TIPS) in patients with cirrhosis and refractory ascites resulted in either resolution or reduction of ascites. [4][5][6][7][8] However, other mechanisms are also likely to be involved, because post-TIPS ascites-free patients with cirrhosis continue to demonstrate a degree of sodium retention when challenged with a sodium load despite a normal portal-systemic gradient. 9 This occurs despite an adequately filled effective arterial blood volume (EABV) as shown by normal plasma renin activity, plasma aldosterone, and norepinephrine (PNE) levels, 9 suggesting that it is not underfilling of the EABV as described by the Peripheral Arterial Vasodilatation Hypothesis 10 that is responsible for the sodium retention on sodium challenge in these patients.…”
mentioning
confidence: 99%
“…Numerosi trials controllati hanno comparato l'efficacia della TIPS con la terapia medica ed endoscopica nella profilassi del sanguinamento da varici e nel trattamento dell'ascite refrattaria, che rimangono le principali indicazioni, univocamente condivise [1][2][3][4][5][6][7]; le linee guida alla procedura sono state tracciate sulla base di aspetti tecnici angiografici, fattori prognostici clinico-laboratoristici ed incidenza di complicanze. Indicazioni più rare ed oggetto di studi non controllati condotti su piccoli gruppi di pazienti, alcune delle quali non uniformemente accettate sono: la trombosi portale, la sindrome di Budd-Chiari, l'ascite pleurica [8][9][10], la sindrome epato-polmonare (HPS) [11], la sindrome epato-renale (HRS) [3,[12][13][14][15][16][17], la profilassi del sanguinamento intraoperatorio in pazienti cirrotici con ipertensione portale candidati ad interventi di chirurgia addominale maggiore [8,18,19] e la tutela della pervietà portale pre-trapianto epatico (OLT) [20,21].…”
Section: Da Oltre 20 Anni Lo Shunt Intraepatico Porto-sistemico (Tipsunclassified
“…A number of controlled trials have compared the efficacy of TIPS versus medical and endoscopic treatment in preventing variceal bleeding and treating refractory ascites, to date the universally accepted indications for TIPS [1][2][3][4][5][6][7]. Guidelines for the procedure have been established on the basis of technical angiographic aspects, clinical and laboratory prognostic factors and complication rate.…”
Section: Introductionmentioning
confidence: 99%
“…The purpose of TIPS is to decompress the portal system and therefore treat the complications of portal hypertension. TIPS has been proven to be an effective treatment for secondary prevention of variceal bleeding, as well as refractory cirrhotic ascites, with controlled trials (2)(3)(4)(5). Besides these, TIPS has been used in a variety of different clinical conditions, including Budd-Chiari syndrome (BCS).…”
Section: Transjugular Intrahepatic Portosystemic Shunt (Tips)mentioning
confidence: 99%