The North Staffordshire Osteoarthritis Project – NorStOP: Prospective, 3-year study of the epidemiology and management of clinical osteoarthritis in a general population of older adults

Thomas, Elaine; Wilkie, Ross; Peat, George; Hill, Susan; Dziedzic, Krzysztof; Croft, Peter

doi:10.1186/1471-2474-5-2

Cited by 111 publications

(130 citation statements)

References 17 publications

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“…Participants who responded were slightly younger than nonrespondents (mean age 66.5 versus 66.3 years; t ϭ 5.0, P ϭ 0.01), and women were more likely to respond compared with men (56.5% versus 43.5%; 2 [1] ϭ 46.6, P ϭ 0.01). Data were therefore weighted by age and sex to adjust for nonresponse bias to determine prevalence estimates, with 95% confidence intervals calculated according to the method described by Schoenberg (13).…”

Section: Discussionmentioning

confidence: 99%

“…It has been estimated that 15% of the adult population have musculoskeletal problems (1), with 2 out of 3 persons over the age of 50 reporting recent musculoskeletal pain (2). Individuals reporting such pain represent a considerable direct and indirect cost to health care services (3,4) and are more likely to have poorer general health (5) and greater levels of depression (6), anxiety (7), physical disability (2,8), and associated lost productivity in the workforce (9,10).…”

Section: Introductionmentioning

confidence: 99%

“…Individuals reporting such pain represent a considerable direct and indirect cost to health care services (3,4) and are more likely to have poorer general health (5) and greater levels of depression (6), anxiety (7), physical disability (2,8), and associated lost productivity in the workforce (9,10). Although there is some limited recognition that the presentation of multiple joint problems is common (2), the focus of management strategies is still aimed at individual joint problems: indeed, the functional impact on daily tasks of the most common multiple joint combinations has not been explored.…”

Section: Introductionmentioning

confidence: 99%

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Impact of multiple joint problems on daily living tasks in people in the community over age fifty‐five

Keenan¹,

Tennant²,

Fear³

et al. 2006

Arthritis & Rheumatism

136

155

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Objective. To establish the prevalence of multiple joint problems and their impact on everyday tasks. Methods. A random sample of the UK population was assessed using a postal questionnaire. Data on overall joint pain, swelling and stiffness, and activities of daily living were obtained from 16,222 individuals >55 years of age (86% response rate). Prevalence estimates of joint problems were established and the impact of multiple joint pathologies on common physical tasks was determined. Results. Single joint involvement was unusual (median joint involvement 4). Although the knee was the most frequently involved joint (220.30 per 1,000), isolated knee pathology accounted for only 1 in 11 patients with knee pain. Although single joint disorders increased the risk of experiencing functional difficulty, this risk was substantially increased with multiple joint problems: individuals with knee and feet problems were 14 times more likely to experience difficulty standing and walking than those without knee problems (odds ratio [OR] 14.50); knee and hip problems increased the risk >12 times (OR 12.43) whereas knee, back, feet, and hip involvement increased the risk 60 times (OR 62.41). Conclusion. Multiple-site joint problems are much more common than single joint problems. Although individual joint problems have a considerable impact on a person's functional ability, this risk is substantially increased when other joints are involved. With the increasing burden associated with the aging population, it is essential that the management of joint pain be considered in light of the impact of multiple, rather than single, joint problems.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of multiple joint problems on daily living tasks in people in the community over age fifty‐five

Keenan¹,

Tennant²,

Fear³

et al. 2006

Arthritis & Rheumatism

136

155

View full text Add to dashboard Cite

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“…Participants were drawn from the 6-year followup of the North Staffordshire Osteoarthritis Project (NORSTOP), the details of which have been described elsewhere (30). In summary, the baseline sampling frame consisted of all adults age Ն50 years registered with 3 general practices (n ϭ 11,309) from the North Staffordshire Primary Care Research Consortium.…”

Section: Methodsmentioning

confidence: 99%

Impact of hallux valgus severity on general and foot‐specific health‐related quality of life

Menz¹,

Roddy²,

Thomas³

et al. 2011

Arthritis Care & Research

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173

154

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Objective. To explore the prevalence of and factors associated with hallux valgus and to assess the impact of hallux valgus severity on general and foot-specific health-related quality of life (HRQOL) in older people. Methods. People age >56 years who participated in the 6-year followup of the North Staffordshire Osteoarthritis Project (n ‫؍‬ 2,831) completed a survey that included the Medical Outcomes Study Short Form 36 (SF-36) health survey and the Manchester Foot Pain and Disability Index (FPDI). Self-reported hallux valgus severity was assessed using a validated instrument. Comparisons of SF-36 and FPDI scores were made across 5 severity grades of hallux valgus. Results. Hallux valgus was present in 36.3% of the study population and was associated with female sex, older age, and pain in other bodily regions. There was a progressive reduction in all SF-36 component scores as the severity of hallux valgus increased; this association remained after adjusting for age, sex, education, and body mass index. The strength of these associations diminished after also adjusting for pain in the back, hip, knee, and foot, but hallux valgus severity remained significantly associated with reduced physical function, bodily pain, general health, social function, and mental health subscale scores. Among participants with foot pain, increasing hallux valgus severity was also significantly associated with greater impairment on the pain and function subscales of the FPDI after adjusting for age, sex, and body mass index. Conclusion. There is a progressive reduction in both general and foot-specific HRQOL with increasing severity of hallux valgus deformity.

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“…The study protocol was approved by North Staffordshire Local Research Ethics Committee (project number 1430) and details have been published elsewhere (12,13). All participants provided written informed consent to undergo clinical and radiographic assessment.…”

Section: Methodsmentioning

confidence: 99%

Estimating the probability of radiographic osteoarthritis in the older patient with knee pain

Peat

Thomas

Duncan

et al. 2007

Arthritis & Rheumatism

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Objective. To determine whether clinical information can practically rule in or rule out the presence of radiographic osteoarthritis in older adults with knee pain. Methods. We conducted a cross-sectional diagnostic study involving 695 adults ages >50 years reporting knee pain within the last year identified by postal survey and attending a research clinic. Potential indicators of radiographic osteoarthritis were gathered by self-complete questionnaires, clinical interview, and physical examination. Participants underwent plain radiography (posteroanterior, skyline, and lateral views). Radiographic osteoarthritis was defined as the presence of definite osteophytes in at least 1 joint compartment of the index knee. Results. Independent predictors of radiographic osteoarthritis were age, sex, body mass index, absence of whole leg pain, traumatic onset, difficulty descending stairs, palpable effusion, fixed-flexion deformity, restricted-flexion range of motion, and crepitus. Using this model, 245 participants had a predicted probability >80% (practical rule in), of whom 231 (94%) actually had radiographic osteoarthritis (specificity 93%). Twenty-one participants had a predicted probability <20% (practical rule out), of whom only 2 (10%) had radiographic osteoarthritis (sensitivity 99.6%). The predicted probability of radiographic osteoarthritis for the remaining 429 participants fell into an intermediate category (20 -79%). Conclusion. Simple clinical information can be used to estimate the probability of radiographic osteoarthritis in individual patients. However, for the majority of community-dwelling older adults with knee pain this method enables the presence of radiographic osteoarthritis to be neither confidently ruled in nor ruled out. Prospective validation and updating of these findings in an independent sample is required.

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The North Staffordshire Osteoarthritis Project – NorStOP: Prospective, 3-year study of the epidemiology and management of clinical osteoarthritis in a general population of older adults

Cited by 111 publications

References 17 publications

Impact of multiple joint problems on daily living tasks in people in the community over age fifty‐five

Impact of multiple joint problems on daily living tasks in people in the community over age fifty‐five

Impact of hallux valgus severity on general and foot‐specific health‐related quality of life

Estimating the probability of radiographic osteoarthritis in the older patient with knee pain

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