The Notch Signaling Pathway Is Related to Neurovascular Progression of Pancreatic Cancer

Büchler, Peter; Gazdhar, Amiq; Schubert, Mario; Giese, Nathalia A.; Reber, Howard A.; Hines, Oscar J.; Giese, Thomas; Ceyhan, Güralp O.; Müller, Michael; Büchler, Markus W.; Frieß, Helmut

doi:10.1097/01.sla.0000189115.94847.f1

Cited by 92 publications

(72 citation statements)

References 38 publications

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“…It consists of two cleavages, occurring at the extracellular side, followed by a third cleavage that liberates the intracellular Notch receptor domain, which is translocated to the cell nucleus (40,41), where it regulates the balance between cell differentiation and stem cell proliferation, during the development of numerous tissues, including the pancreas (34,42). It is likely that this latter form participates in neoplastic cell transformation in several organs, such as the cervix, uteri, lung, breast, nerve tissue and also in the pancreas (43)(44)(45)(46)(47). However, the cases of staining in PDAC that we found were uniformly cytoplasmic, with no nuclear Notch2 and Notch3 being observed in any case; it is thus likely that tumors expressing nuclear Notch2 and Notch3 had been found to be non-resectable.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma

Vizio

Mauri²,

Prati³

et al. 2011

Oncol Rep

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Section: Discussionmentioning

confidence: 99%

Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma

Vizio

Mauri²,

Prati³

et al. 2011

Oncol Rep

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“…The Notch signaling pathway is involved in the carcinogenesis, progress, invasion and neurovascular formation of many malignant tumors (22,(33)(34)(35). The Notch signaling pathway can regulate MMP-2, MMP-9 and VEGF (22,(36)(37)(38)(39)(40), which are important in the processes of invasion and metastasis of tumor.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of the Notch signaling pathway inhibits hepatocellular carcinoma cell invasion by inactivation of matrix metalloproteinase-2 and -9 and vascular endothelial growth factor

Zhou¹,

Wang

Liu

et al. 2012

Oncology Reports

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Abstract. Hepatocellular carcinoma (HCC) is one of the most common malignancies. The main cause of death in HCC patients is tumor progression with invasion and metastasis. However, the underlying mechanisms of HCC invasion and metastasis are still not fully understood. Some studies show that the Notch signaling pathway may participate in tumor invasion and metastasis. However, the mechanisms by which the Notch signaling pathway mediates tumor cell invasion, especially in hepatocellular carcinoma, are not yet known. In the current study, we investigated the anti-invasion effect of the downregulation of the Notch signaling pathway by DAPT in HCC cells. The Notch signaling pathway inhibitor could suppress invasion of HCC cells via the extracellular signalregulated kinases 1 and 2 (ERK1/2) signaling pathways, resulting in the downregulation of matrix metalloproteinase-2 and -9 (MMP-2 and -9) and vascular endothelial growth factor (VEGF). These observations suggested that inhibition of the Notch signaling pathway by DAPT would be useful for devising novel preventive and therapeutic strategies targeting invasion of HCC.

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“…Therefore, it is clear that alterations in Notch signaling are associated with carcinogenesis of the pancreas. We and others have found that Notch signaling is frequently deregulated in human pancreatic cancers (Wang et al, 2006e;Wang et al, 2006a;Buchler et al, 2005). High expression of Notch, which inhibits apoptosis, has been found in pancreatic cancers.…”

Section: Activation Of Oncogenesmentioning

confidence: 99%

Pancreatic cancer: Pathogenesis, prevention and treatment

Sarkar

Banerjee

2007

Toxicology and Applied Pharmacology

104

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Pancreatic cancer is the fourth leading cause of cancer death in the United States with a very low survival rate of 5 years. To better design new preventive and/or therapeutic strategies for the fight against pancreatic cancer, the knowledge of the pathogenesis of pancreatic cancer at the molecular level is very important. It has been known that the development and the progression of pancreatic cancer are caused by the activation of oncogenes, the inactivation of tumor suppressor genes, and the deregulation of many signaling pathways among which the EGFR, Akt, and NF-κB pathways appear to be most relevant. Therefore, the strategies targeting EGFR, Akt, NF-κB, and their downstream signaling could be promising for the prevention and/or treatment of pancreatic cancer. In this brief review, we will summarize the current knowledge regarding the pathogenesis, prevention, and treatment of pancreatic cancer.

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The Notch Signaling Pathway Is Related to Neurovascular Progression of Pancreatic Cancer

Cited by 92 publications

References 38 publications

Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma

Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma

Downregulation of the Notch signaling pathway inhibits hepatocellular carcinoma cell invasion by inactivation of matrix metalloproteinase-2 and -9 and vascular endothelial growth factor

Pancreatic cancer: Pathogenesis, prevention and treatment

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