The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model

Li, Yanfang; Ma, Liping; Deng, Yongbo; Du, Ziwei; Guo, Bingqian; Yue, Jianing; Liu, Xianxian; Zhang, Ying-hua

doi:10.1016/j.neuropharm.2023.109682

Cited by 4 publications

(1 citation statement)

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“…However, it has been revealed that the epithelial cells of patients with IBD have lower levels of DNMT3A, and IECs that lack functional DNMT3A are more vulnerable to experimental colitis ( 40 ). This further corroborates other findings by Li et al ( 41 ), who found that DNMT3A protein expression was reduced in the prefrontal cortex, hippocampus and cerebellum of rats with valproic acid-induced autism spectrum disorder.…”

Section: Enzymes and Proteins Involved In Dnam And Ibdsupporting

confidence: 92%

Effects of DNA methylation and its application in inflammatory bowel disease (Review)

Akanyibah,

Zhu,

Wan

et al. 2024

Int J Mol Med

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Inflammatory bowel disease (IBD) is marked by persistent inflammation, and its development and progression are linked to environmental, genetic, immune system and gut microbial factors. DNA methylation (DNAm), as one of the protein modifications, is a crucial epigenetic process used by cells to control gene transcription. DNAm is one of the most common areas that has drawn increasing attention recently, with studies revealing that the interleukin (IL)-23/IL-12, wingless-related integration site, IL-6-associated signal transducer and activator of transcription 3, suppressor of cytokine signaling 3 and apoptosis signaling pathways are involved in DNAm and in the pathogenesis of IBD. It has emerged that DNAm-associated genes are involved in perpetuating the persistent inflammation that characterizes a number of diseases, including IBD, providing a novel therapeutic strategy for exploring their treatment. The present review discusses DNAm-associated genes in the pathogenesis of IBD and summarizes their application as possible diagnostic, prognostic and therapeutic biomarkers in IBD. This may provide a reference for the particular form of IBD and its related methylation genes, aiding in clinical decision-making and encouraging therapeutic alternatives.

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Section: Enzymes and Proteins Involved In Dnam And Ibdsupporting

confidence: 92%