The Novel 6–(N-Pyrrolyl)purine Acyclic Nucleosides:¹H and¹³C NMR and X-ray Structural Study†

Crystal structure of 9-methyl-(6-N-pyrrolyl)purine, C10H9N5

“…The observed values for bond distances and angles of the N-pyrrolyl and purine ring are in a good agreement with those found in the other (6-N-pyrrolyl)purine derivatives [2,3]. …”

“…As a part of research in our laboratories to develop novel anticancer and antiviral agents we prepared a derivative of (6-N-pyrrolyl)purine [2].…”

Synthesis and Structure Elucidation of (R)‐3‐(2′‐hydroxyprop‐1‐yl) adenine

“…No N-1 alkylation was found. On the other hand, Raić [8] has reported on concurrent formation of N-9 and N-7 regioisomers in the alkylation reactions of 6-(N-pyrrolyl) purine, as confirmed by 1 H-NMR and 13 C-NMR spectroscopy. On the basis of single crystal X-ray diffraction analysis, it shows that (R)-3-(2′-hydroxyprop-1-yl) adenine 4 with 3 were obtained by alkylation of adenine 1 with R-propylene carbonate 2 in the presence of pulverized sodium hydroxide.…”

Synthesis and Applications of Azolylpurine and Azolylpurine Nucleoside Derivatives

“…[29] Cyclization Approach with Aminopurine Derivatives Combination of naturally occurring adenine with 1,4-dicarbonyl compounds or their masked equivalents results in the formation of 6-(N-pyrrolyl)purines such as 56a (Scheme 14). [30,31] Inspired by the antiviral activity of acyclovir, alkylation of intermediate 56a was undertaken, and N(9)-and N(7)-substituted acyclic derivatives 60-62 were obtained. Purines with heterocyclic substituents at C(6) were investigated as inactivation modifiers for the cardiac sodium channels of guinea pigs and humans.…”