The novel coronary artery disease risk factor ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1

Sharifi, Amin M.; Wierer, Michael; Dang, Tan An; Milić, Jelena; Moggio, Aldo; Sachs, Nadja; Scheidt, Moritz von; Hinterdobler, Julia; Müller, Philipp; Werner, Julia; Stiller, Barbara; Aherrahrou, Zouhair; Erdmann, Jeanette; Zaliani, Andrea; Graettinger, Mira; Reinshagen, Jeanette; Gul, Sheraz; Gribbon, Philip; Maegdefessel, Lars; Sager, Hendrik B.; Mann, Matthias; Schunkert, Heribert; Kessler, Thorsten

doi:10.1101/2023.03.06.531428

Cited by 1 publication

(1 citation statement)

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“…Coronary artery disease (CAD) and acute myocardial infarction (MI) are multifactorial diseases influenced by lifestyle and genetic predisposition [20]. Our group contributed before to the identification of novel CAD-relevant genes, biomarkers, and treatment possibilities [21][22][23][24][25][26][27][28]. Treatment of flow-limiting coronary lesions with percutaneous coronary intervention (PCI) is the current standard of care.…”

Section: Introductionmentioning

confidence: 99%

Machine Learning Identifies New Predictors on Restenosis Risk after Coronary Artery Stenting in 10,004 Patients with Surveillance Angiography

Güldener

Kessler

Scheidt

et al. 2023

JCM

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Objective: Machine learning (ML) approaches have the potential to uncover regular patterns in multi-layered data. Here we applied self-organizing maps (SOMs) to detect such patterns with the aim to better predict in-stent restenosis (ISR) at surveillance angiography 6 to 8 months after percutaneous coronary intervention with stenting. Methods: In prospectively collected data from 10,004 patients receiving percutaneous coronary intervention (PCI) for 15,004 lesions, we applied SOMs to predict ISR angiographically 6–8 months after index procedure. SOM findings were compared with results of conventional uni- and multivariate analyses. The predictive value of both approaches was assessed after random splitting of patients into training and test sets (50:50). Results: Conventional multivariate analyses revealed 10, mostly known, predictors for restenosis after coronary stenting: balloon-to-vessel ratio, complex lesion morphology, diabetes mellitus, left main stenting, stent type (bare metal vs. first vs. second generation drug eluting stent), stent length, stenosis severity, vessel size reduction, and prior bypass surgery. The SOM approach identified all these and nine further predictors, including chronic vessel occlusion, lesion length, and prior PCI. Moreover, the SOM-based model performed well in predicting ISR (AUC under ROC: 0.728); however, there was no meaningful advantage in predicting ISR at surveillance angiography in comparison with the conventional multivariable model (0.726, p = 0.3). Conclusions: The agnostic SOM-based approach identified—without clinical knowledge—even more contributors to restenosis risk. In fact, SOMs applied to a large prospectively sampled cohort identified several novel predictors of restenosis after PCI. However, as compared with established covariates, ML technologies did not improve identification of patients at high risk for restenosis after PCI in a clinically relevant fashion.

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