The novel coronavirus SARS-CoV-2 and pregnancy: literature review

Priputnevich, Priputnevich T.V.; Gordeev, Gordeev A.B.; Lyubasovskaya, Lyubasovskaya L.A.; Shabanova, Shabanova N.E.

doi:10.18565/aig.2020.5.6-12

Cited by 14 publications

(5 citation statements)

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“…На особливу увагу заслуговують інфекційні процеси екстрагенітальних і генітальних органів, які в свою чергу обтяжують клінічний перебіг основного захворювання [3]. Наслідки дії інфекційних агентів, особливо вірусів, як поліетіологічного інфікування в організмі жінки можуть сприяти виникненню вторинного імунодефіциту, порушенню ендокринної функції яєчників, системи згортання крові, ендотеліальної дисфункції [7,9]. Особливо тяжко перебігає захворювання у жінок обтяжених серцево-судинною патологією, інфекційними процесами, дисгормональними розладами, що сприяють гіперкоагуляції, порушенню мікроциркуляції крові, тромбоутворенню.…”

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Clinical assessment of the condition of women of reproductive age with adenomyosis after experiencing COVID-19

Bulgar¹

2023

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The relevance of the gynecological disease adenomyosis (N80.0) is beyond doubt, as this pathology is a serious problem today both in medicine and in society. The aim is to study the clinical condition of women of reproductive age with adenomyosis after suffering COVID-19. 150 women of reproductive age were examined after suffering COVID-19 disease, 120 of them with adenomyosis. The results obtained were processed using the methods of mathematical statistics and using the MS Excel XP, Statistica 6.0 software package using Student's parametric test. At the same time, differences were considered statistically significant at p<0.05. A clinical assessment of the condition of women of reproductive age with adenomyosis after suffering COVID-19 confirmed a significantly more severe course of adenomyosis in the early post-COVID period. After undergoing COVID-19, the frequency of complaints of general malaise, headaches, lethargy, pain in the joints, muscles, and pelvis in women aggravated by adenomyosis significantly increased. The more severe the degree of the disease (I-II, III-IV), the worse was the general condition of the examined patients. The frequency of complaints about general malaise, exacerbation of extragenital diseases (cardiovascular system, gastrointestinal tract, hepatobiliary system, anemia, etc.), gynecological pathology, including disorders of menstrual function, volume of menstrual blood loss, pelvic pain syndrome, presence of processes of inflammatory (infectious) etiology increased significantly. Determining the clinical assessment of the condition of women of reproductive age with adenomyosis after suffering COVID-19 is of fundamental practical importance for determining the tactics of managing this cohort of patients with the aim of timely qualified prevention of possible complications. Prospects for further research are aimed at developing and implementing an algorithm for managing women of reproductive age with adenomyosis after suffering COVID-19.

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Clinical assessment of the condition of women of reproductive age with adenomyosis after experiencing COVID-19

Bulgar¹

2023

Rep. of Vinnytsia Nation. Med. Univ.

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“…Відомо, що коронавірус -це РНК-вмісний вірус, що належить до родини Coronaviridae ряду Nidovirales [5]. В інфікованих людей розвиваються тяжкі клінічні прояви у вигляді ураження ЦНС та серцево-судинної системи, органів дихання, кишечника, нирок тощо [25].…”

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“…З літературних джерел відомо про різні клінічні форми COVID-19. Є дані, які вказують на наявність асциту в черевній порожнині, везикулярних висипань на внутрішніх органах, клінічні ознаки перитоніту, що є показанням до ургентного хірургічного втручання тощо [5,20].…”

Section: вступunclassified

“…В літературі є дані, які вказують на запалення очеревини при коронавірусі -«новий ковід, що перебігає з клінікою серозного перитоніту» [4,5]. Вчені висловили припущення, що запалення очеревини при COVID-19 може виникнути внаслідок системної відповіді на вірусну інфекцію, яка супроводжується масивною продукцією цитокінів, гіперактивацією клітин імунітету та утворенням циркулюючих імунних комплексів, що може призводити до патологічних змін у мікросудинах і асеп- Враховуючи вищенаведене, вагітним і породіллям доцільно призначати вітамінно-макро-мікроелементні комплекси для підтримки, стабілізації окисно-відновних процесів, фолатного циклу та циклу Кребса в їх організмі, в тому числі вітамін D та мікроелемент магнію.…”

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Features of the postcovid period in women in labor

Міщенко

Shpak

Руденко

et al. 2021

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Clinical manifestations in the abdominal cavity of a woman in labor, discovered during an urgent cesarean section at 41 weeks of gestation 2 months after an acute form of COVID-19, are described. The materials of medical documentation were analyzed and the features of the course of pregnancy by trimester, urgent cesarean section, postoperative period, laboratory parameters, ultrasound data, cardiotocography, fetal condition at birth and three days later were determined.Presentation of case. 33-year-old pregnant woman (pregnant for the first time) had COVID-19 at 26 weeks of gestation. At a cesarean section for urgent indications at 41 weeks of gestation during the revision of the abdominal cavity was found that the visceral peritoneum of the uterus along the anterior and posterior surfaces, fallopian tubes, wide and round uterus ligaments, ovaries and parietal peritoneum of the pelvis, areas of the serous intestinal layer were with expressive signs of edema covered with vesicular rash, in places in the conglomerate, which were bleeding. There was no abdominal effusion.The child was born with 7–8 points Apgar score and had a negative PCR result for COVID-19. Placenta measuring 25 x 21 x 5.0 x 0.5 cm with multiple petrification, single red heart attacks. The shells are distinctly yellow-gray-green in color. The umbilical cord is 70 cm long and usual color. Amniotic fluid is clear. The early and late postoperative periods and the postpartum period proceeded without complications. At once the disorders in the blood coagulation system, immune system, positive COVID-19 IgG and IgM were identified in mother. Videin, Magniсum-antistress, preparations of acetylsalicylic acid and for the comprehensive support of the physiological state of the intestine were used in the complex treatment of the postpartum period.Conclusion. COVID-19 disease is pathology with many unknowns. Therefore, each clinical observation is important for studying of its course. Post-COVID syndrome and long-COVID syndrome have individual characteristics. Collective experience will contribute to the definition of an algorithm for the therapy of patients and personalized dispensary observation after an acute period.

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“…За даними науковців, патологічна симптоматика після гострого періоду COVID-19 може виникати і внаслідок ендотеліальної дисфункції, ендотеліозу, тромбоваскуліту тощо [6], які є ланцюгами патогенетичного кола, причиною, наслідком багатьох захворювань різної етіології. Судинні ускладнення клінічно перебігають гостро або з періодичними загостреннями [14,16,24] і завжди супроводжуються порушенням мікроциркуляції та тромбоутворенням, можуть мати тяжкі наслідки для організму загалом і для клінічного перебігу аденоміозу тощо.…”

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Features of the management of reproductive aged women with adenomyosis in the post-COVID period

Булгар

Zaporozhchenko

2023

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Objectives: development of an algorithm for managing women of reproductive age with adenomyosis of I–IV degrees of severity after COVID-19 by studying anamnestic, clinical, laboratory indicators, results of instrumental and hardware research and determining personalized therapy and prevention.Materials and methods. We monitored 120 reproductive aged women with adenomyosis after COVID-19, who were divided into group B (60 women with adenomyosis of the I–II degree of severity) and group C (60 women with adenomyosis of the III–IV degree of severity). Groups B and C were divided into 2 subgroups: subgroups B1 and C1 received the proposed therapy; subgroups B2 and C2 received standard therapy.All women underwent a clinical and laboratory examination, which included the study of the general condition, clinical and biochemical parameters, examination of biological fluids (blood, urine, vaginal contents), histomorphological study of the tissues of uterus, ovaries, hardware and instrumental methods of examination. The results were evaluated before treatment, after 3, 6 and 12 months of therapy, comparing between groups B and C.Results. The effectiveness of the proposed algorithm is confirmed by a significant difference (p < 0.05) in the reduction of the frequency of complaints, symptoms of exacerbation of extragenital and gynecological pathology, stabilization of indicators of general blood test, functional liver tests, lipid and cholesterol metabolism, reduction of indicators of hypercoagulation, activity of biological markers of inflammatory processes, increase the vitamin D and magnesium values, positive changes in the vaginal biocenosis, a decrease in the frequency of herpes simplex virus types 1 and 2 detection, an increase in the number of Lactobacillus sp., positive dynamics of uterine ultrasound parameters, including the state of blood flow in a. uterus in the observation dynamics after 3, 6 and 12 months.Conclusions. Women of reproductive age with adenomyosis of various degrees of severity after suffering from the COVID-19 disease are subject to personalized dispensary supervision, which includes diagnostic, therapeutic, preventive measures in the dynamics of observation. The definition of the measures of such algorithm should be based on the results of proven pathological changes in the body, namely: exacerbation of extragenital diseases, combined gynecological pathology, blood hypercoagulation and microcirculation disorders, activity of biological markers of inflammation, levels of sex hormones, vitamin D, magnesium, state of vaginal biocenosis.

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The novel coronavirus SARS-CoV-2 and pregnancy: literature review

Cited by 14 publications

References 0 publications

Clinical assessment of the condition of women of reproductive age with adenomyosis after experiencing COVID-19

Clinical assessment of the condition of women of reproductive age with adenomyosis after experiencing COVID-19

Features of the postcovid period in women in labor

Features of the management of reproductive aged women with adenomyosis in the post-COVID period

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