The novel dopamine D3 receptor antagonist, SR 21502, reduces cocaine conditioned place preference in rats

A selective D3 receptor antagonist YQA14 attenuates methamphetamine-induced behavioral sensitization and conditioned place preference in mice

“…These results suggest that D 3 Rs play a more important role in the expression of conditioned behaviors than in their acquisition [47,50] . Regardless of the mechanisms underlying the ineffectiveness of YQA14 at combatting the acquisition of METH-induced CPP, the present finding that YQA14 inhibits the expression of METH-induced CPP is consistent with previous reports that have shown that the blockade of D 3 Rs by SB-277011A, YQA14 or SR21502 inhibits cocaine-induced CPP [14,22,51] , cocaine and METH self-administration [12,18,21,31] , and cocaine-and METHinduced enhancement of electrical brain stimulation rewards [21,33,35] . Importantly, YQA14 itself does not induce CPP or CPA [22] .…”

“…All animals were then returned to their home cages without METH or saline treatment for a 7-d withdrawal period (d [14][15][16][17][18][19][20]. Finally, all of the mice were challenged with METH (0.5 mg/kg, ip) on d 21.…”

“…Various compounds with D 3 R antagonist profiles, such as YQA14, SB-277011A, NGB2904, BP-897, S-33138, PG-01037, and SR21502, have been evaluated for the treatment of addiction to psychostimulants, particularly cocaine, in experimental animals [10,[12][13][14][15] . However, few studies have evaluated the potential use of these compounds for the treatment of METH addiction.…”

Dopamine D3Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs

“…The dopamine D 3 receptor antagonist NGB 2904 attenuated cocaine selfadministration, reduced cocaine-induced extracellular dopamine, and inhibited both cue-and prime-induced relapse Xi and Gardner, 2007). The dopamine D 3 receptor antagonist S33138 attenuated cocaine-enhanced brain stimulation reward and priming-induced relapse (Peng et al, 2009), and the dopamine D 3 receptor antagonist SR 21502 reduced cocaine-conditioned place preference (Hachimine et al, 2014), cue-induced relapse, and cocaine selfadministration (Galaj et al, 2014). The dopamine D 3 receptor antagonist PG01037 reduced cocaine-primed relapse in squirrel monkeys (Achat-Mendes et al, 2010), and the dopamine D 3 receptor antagonist YQA14 reduced cocaine-enhanced brain stimulation reward and attenuated cue-induced relapse (Song et al, 2014), as well as cocaine self-administration (Song et al, 2012) in rats.…”

Microinjections of a dopamine D1 receptor antagonist into the ventral tegmental area block the expression of cocaine conditioned place preference in rats

“…Cocaine can be used to establish a conditioned place preference [42,[44][45][46]. This preference is associated with DA release in terminal regions of the mesocorticolimbic DA system [47] and is dependent on this DA release [48][49][50][51][52][53]. As reviewed above, stimulation of VTA DA D1 receptors plays a role in the rewarding effects of cocaine itself.…”