The novel FAAH inhibitor, MCH1, reduces the infarction area in the motor cortex-related region but does not affect the sensorimotor function or memory and spatial learning in rats exposed to transient middle cerebral artery occlusion

Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs

“…Some other types of natural products also have FAAH inhibition effects. Macamides, a unique series of non-polar long-chain fatty acids N-benzamide isolated from Maca, are mainly alkaloids with neuroprotective properties, 223 of which N-Benzyloctadeca-9Z,12Z-dienamide exhibits the best FAAH inhibitory activity and attenuates ischaemic stroke injury, 224 but this inhibition is an irreversible inhibitor that exhibits time-dependent inhibition. 205 Lavender essential oil, an over-The-counter herbal medicine approved by the European Medicines Agency for the relief of anxiety, displayed FAAH inhibitory activity in vitro and produced effects comparable to diazepam in mice.…”