2005
DOI: 10.1016/j.ijpharm.2005.08.022
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The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds

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Cited by 88 publications
(32 citation statements)
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“…As delivery systems, emulsions should increase drug solubility and permeability, prevent drug hydrolysis or early enzymatic degradation, deliver the drug in a controlled manner and facilitate its transport (Araya et al 2005;Ganta et al 2010). Compounds with different solubility can be encapsulated and their distribution in one of the three regions of the emulsion will depend on their concentration and polarity (McClements 2015).…”
Section: Emulsionsmentioning
confidence: 99%
“…As delivery systems, emulsions should increase drug solubility and permeability, prevent drug hydrolysis or early enzymatic degradation, deliver the drug in a controlled manner and facilitate its transport (Araya et al 2005;Ganta et al 2010). Compounds with different solubility can be encapsulated and their distribution in one of the three regions of the emulsion will depend on their concentration and polarity (McClements 2015).…”
Section: Emulsionsmentioning
confidence: 99%
“…A microemulsion system is considered as an ideal alternative for the oral delivery of some drugs, such as nitrendipine, ibuprofen, and docetaxel. Therefore, employing a microemulsion formulation can improve oral bioavailability (5,6,39). Compared with a daidzein-borneol/menthol eutectic mixture, a daidzein-borneol/menthol microemulsion is a formulation that contains a surfactant (Cremophor RH40, PEG400).…”
Section: Discussionmentioning
confidence: 99%
“…A variety of formulation strategies have been developed to improve the solubility and bioavailability of such drugs. These strategies include using absorption enhancers (1,2), chemical modification (3,4), and different dosage forms (e.g., microemulsion) (5,6). The use of absorption enhancers is the most common.…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless, the therapeutic use of microemulsions as an oral dosage form is negligible. The main limiting factors are large volumes and composition requirements, namely, a high ratio of surfactants that are potentially toxic (26,32,54,55).…”
Section: Types Of Lipid-based Drug Delivery Systemsmentioning
confidence: 99%