The novel ischemia marker ‘ischemia‐modified albumin’ is increased in normal pregnancies

Güven, Süleyman; Alver, Ahmet; Menteşe, Ahmet; Ilhan, Fulya; Calapoğlu, Mustafa; Ünsal, Mesut A.

doi:10.1080/00016340902777517

Cited by 43 publications

(25 citation statements)

References 13 publications

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“…There were also many reports showing its relationship with various ischemia‐related conditions, such as acute coronary syndrome . Recently, in two studies among normal pregnancies, it has been demonstrated that maternal serum IMA levels increased to supra‐physiological levels in the first trimester of pregnancy compared to non‐pregnant controls, and these levels continued to rise from the first trimester to the third trimester . In previous reports, it has been clearly demonstrated that pre‐eclampsia is a disease associated with placental hypoxia and increased oxidative stress occurring concurrently with ischemia .…”

Section: Discussionmentioning

confidence: 97%

Cord blood ischemia‐modified albumin: Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia?

Kumral

Okyay

Güçlü

et al. 2012

J of Obstet and Gynaecol

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Aim: To evaluate the significance of the cord blood ischemia-modified albumin (IMA) level as a diagnostic marker for perinatal asphyxia and to determine the associations of IMA levels with the complexity of pregnancy and abnormal Doppler findings, regardless of perinatal asphyxia. Methods: This prospective study included 169 newborns, sixteen of whom had perinatal asphyxia and 33 who were from complicated pregnancies. Doppler measurements were obtained from the uterine, umbilical and middle cerebral arteries, and the cerebro/placental ratio (C/P). IMA was measured by means of commercially available ELISA kits and was expressed as picomoles per milliliter. Results: Ischemia-modified albumin levels were significantly higher in neonates of complicated pregnancies as compared to uncomplicated pregnancies (P < 0.0001). They were higher in newborns with perinatal asphyxia as compared to healthy controls (P = 0.015). The C/P ratio-pulsatility index (PI) showed a significant difference between normal and complicated pregnancies without perinatal asphyxia (P < 0.0001). IMA levels were significantly increased in cases with abnormal C/P ratio-PI. Conclusions: Elevated cord blood IMA levels may be accepted as a useful marker in perinatal asphyxia. Abnormal Doppler examinations are associated with elevated IMA levels in complicated pregnancies.

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Section: Discussionmentioning

confidence: 97%

Cord blood ischemia‐modified albumin: Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia?

Kumral

Okyay

Güçlü

et al. 2012

J of Obstet and Gynaecol

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“…Also, ischemia-modified albumin is a new biomarker, and serum IMA levels are also affected by various physiologic changes that cause oxidative stress, such as pregnancy; many comorbid conditions such as malignancy, chronic liver failure, end-stage renal failure, cerebral ischemia, and acute infections have also led to false-positive IMA results. [20][21][22][23] We were not able to control all of the variables that could possibly influence IMA levels. Patients with mesenteric ischemia are usually of advanced age and have comorbid diseases, which reduce the specificity and positive predictive value of the test.…”

Section: Limitationsmentioning

confidence: 99%

The Diagnostic Value of Ischemia-modified Albumin in a Rat Model of Acute Mesenteric Ischemia

Uygun

Yılmaz

Pekdemir

et al. 2011

Academic Emergency Medicine

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Objectives: Previous studies have demonstrated that ischemia-modified albumin (IMA) is a useful marker for the diagnosis of ischemic events. This study aimed to determine the value of ischemia-modified plasma albumin in the early diagnosis of acute mesenteric ischemia in an experimental model. Methods:The study was performed on 32 Wistar albino rats divided into control (n = 8), sham (n = 8), 2-hour (n = 8), and 6-hour (n = 8) ischemia groups. Mesenteric ischemia was created by arterial occlusion, and then blood samples (2 mL) were collected and centrifuged. Serum levels of IMA were measured by a rapid calorimetric test that determined the reduced cobalt binding to albumin. For histopathologic evaluation, samples of the small intestine were obtained from the animals after they were euthanized at the end of the experiment.Results: Histopathologic damage of the intestinal wall correlated with the duration of ischemia. While the mean pathology scores of the 2-and 6-hour ischemia groups were different from each other, IMA levels (mean ± SD) in the four groups were not significantly different from each other: 0.55 ± 0.07 absorbance units (ABSU) in the control group, 0.62 ± 0.09 ABSU in the sham group, 0.60 ± 0.07 ABSU in the 2-hour ischemia group, and 0.64 ± 0.12 ABSU in the 6-hour ischemia group (p = 0.153). Conclusions:Serum IMA values were not useful in the early diagnosis of acute mesenteric ischemia. Further studies to investigate ischemic and nonischemic conditions that affect IMA levels are needed.

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“…IMA levels are mostly more elevated than the concentration detected during myocardial ischemia in women whose pregnancy has just started (Prefumo et al, 2007, Guven et al, 2009, Van Rijn et al, 2008. Moreover, IMA levels become higher in complicated pregnancies than regular ones (Dogan et al, 2015, Karadeniz et al, 2015, Cengiz et al, 2015.…”

Section: Introductionmentioning

confidence: 89%

“…Recent studies show that serum IMA levels are physiologically elevated during normal pregnancies in humans, and that maternal IMA levels are lower than the cutoff which was applied in detecting cardiac ischemia (Prefomu et al, 2007, Guven et al, 2009, Van Rijn et al, 2008.…”

Section: Güvenmentioning

confidence: 99%

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Ischemia modified albumin as an early biomarker in diagnosing the late stages abortus in cows

Yokuş¹,

Ercan²,

Fidancý³

et al. 2017

IJAR

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Nowadays, Ischemia Modified Albumin (IMA) has been regarded as an indicator for various maladies and complicated pregnancy in humans. Therefore, it is hypothesized that evaluation of the maternal serum IMA degrees can serve as an early detection of abortion in dairy cows. 252 Holstein cows' serum samples were taken both in the 2 nd and 6 th months of their pregnancy. Twenty-two cattle were selected as a positive control group among the non aborted ones. Furthermore, blood samples from 20 non-pregnant cows were taken to identify the effects of physiological changes of pregnancy. IMA and Ischemia Modified Albumin Rate (IMAR) were markedly higher (p<0.01); and albumin was markedly lower (p<0.01) in aborted cows and healthy-pregnant cows compared with non-pregnant cows in both months. In aborted cows, IMA, IMAR and Oxidative stress index (OSI) degrees were found to be more increased than healthy pregnancies both in 2 nd and 6 th months of pregnancy; however, there were statistically significant only at 6 th month (p<0.01). Total Oxidative Stress (TOS) levels were higher than healthy pregnancies. So, as a result of IMA which was caused by oxidative stress rising from hypoxia/ischemia could serve as an early bioindicator for miscarriage in cattle.

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The novel ischemia marker ‘ischemia‐modified albumin’ is increased in normal pregnancies

Cited by 43 publications

References 13 publications

Cord blood ischemia‐modified albumin: Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia?

Cord blood ischemia‐modified albumin: Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia?

The Diagnostic Value of Ischemia-modified Albumin in a Rat Model of Acute Mesenteric Ischemia

Ischemia modified albumin as an early biomarker in diagnosing the late stages abortus in cows

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