2004
DOI: 10.1055/s-2004-815763
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The Novel Missense Mutation Methionine 442 Threonine in the Thyroid Hormone Receptor β causes Thyroid Hormone Resistance: A Case Report

Abstract: We report a family with thyroid hormone resistance caused by a novel mutation M442T in the thyroid hormone receptor beta (TRbeta) gene. The 59-year-old propositus and one of his two daughters had typical clinical signs of reduced responsiveness of tissues to thyroid hormones. Thus, elevated free T (3) and T (4) plasma concentrations in coexistance with a diffuse nodular goiter, nonsuppressed TSH, and atrial fibrillation with tachycardia were present in the propositus. His affected daughter also had increased l… Show more

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Cited by 5 publications
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