The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

Lardelli, Michael; Dahlstrand, Jonas; Lendahl, Urban

doi:10.1016/0925-4773(94)90081-7

Cited by 297 publications

(177 citation statements)

References 50 publications

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“…In each case portions of adjacent EGFL-repeats have been fused to form ®ve novel EGFL-repeats; these include: EGFL-repeats 14 and 15, 16 and 17, 20 and 23, and 31 and 32. A similar phenomenon has occurred in NOTCH3 where portions of EGFL-repeats 2 and 3 are fused to form a novel repeat and EGFL-repeat 21 is missing (Lardelli et al, 1994).…”

Section: Discussionmentioning

confidence: 59%

“…In this scenario, the creation of novel EGFL-repeats for 16 ± 17 and 20 ± 23 suggest a more limited or specialized role for NOTCH4/INT3 in mammalian development. A similar argument could be made for NOTCH3 which has lost the equivalent of EGFL-repeat 21 and contains a novel EGFL-repeat composed of portions of repeats 2 and 3 (Lardelli et al, 1994).…”

Section: Discussionmentioning

confidence: 64%

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The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)

1997

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The INT3 gene is frequently rearranged in mouse mammary tumor virus (MMTV)-induced mammary tumors of the CzechII mouse strain. We have completed the nucleotide sequence of the normal 6.5 Kb INT3 RNA and de®ned the intron/exon boundaries of the gene. The open reading frame of INT3 RNA should encode a 200 kd protein which shares 60% homology with the mouse homologue of Drosophila NOTCH. INT3 is unique among other members of the NOTCH family by containing 29 instead of 36 EGF-like repeats in the extracellular domain of the gene product. Five novel EGF-like repeats have been created as consequence of apparent small deletions which have occurred within the coding region for the extracellular domain during evolution. Nucleotide sequence analysis of host-viral junction fragments from nine independent MMTVinduced mammary tumors containing a rearranged INT3 gene reveals that all of the integration events occur within a 174 bp region 3' of the sequences encoding the LIN12 repeats in the INT3 extracellular domain and 5' of the sequences encoding the transmembrane domain. Therefore, the only tumorigenic INT3 mutations resulting from MMTV proviral insertions are those which results in the expression of the intracellular domain. This strongly suggests that MMTV-induced activation of INT3 is manifest in the absence of the regulatory action of the extracellular domain, including the LIN12 repeat sequences, leaving the expressed intracellular domain constitutively free to function in its role in mammary tumorigenesis.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 64%

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)

1997

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“…2b). 33 All Notch protein levels detected on Western blot correspond to their mRNA levels (examples are shown in Fig. 2b-d).…”

Section: Protein Expression Of Dlk1 Jagged1 Notch1 Notch2 and Notch3mentioning

confidence: 83%

High delta‐like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type

Limpt

Chan

Sluis

et al. 2003

Intl Journal of Cancer

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“…Introduction fication based on published sequences [10][11][12]. The cloned fragment is shown in Fig.…”

mentioning

confidence: 99%

Functional conservation of mouse Notch receptor family members

et al. 1996

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The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

Cited by 297 publications

References 50 publications

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)

High delta‐like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type

Functional conservation of mouse Notch receptor family members

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