The Novel Peptide Drug Conjugate OPDC3 Is Highly Active in Different Hematological Malignancies

Miettinen, Juho J.; Ruokoranta, Tanja; Ikonen, Vilma; Huppunen, Maiju-Emilia; Acs, Klara; Lehmann, Fredrik; Heckman, Caroline A.

doi:10.1182/blood-2022-166090

Cited by 2 publications

(1 citation statement)

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“…With the advancement of synthetic biology, genetic engineering, and photogenetics technology, intelligent cell factories based on small molecules and light signal responses are gradually becoming feasible. Stimulus-responsive drug delivery systems utilize endogenous triggering factors such as pH, reactive oxygen species, and enzyme content, as well as exogenous triggering factors such as temperature, light, magnetic field, ultrasound, electric pulse, and high-energy radiation to trigger or enhance drug release, and control the drug release to be turned on and off on demand via remote devices [164][165][166][167].…”

Section: Stimulation Responsivementioning

confidence: 99%

Novel Drug Delivery Systems: An Important Direction for Drug Innovation Research and Development

Chen,

Yang,

Liu

et al. 2024

Pharmaceutics

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The escalating demand for enhanced therapeutic efficacy and reduced adverse effects in the pharmaceutical domain has catalyzed a new frontier of innovation and research in the field of pharmacy: novel drug delivery systems. These systems are designed to address the limitations of conventional drug administration, such as abbreviated half-life, inadequate targeting, low solubility, and bioavailability. As the disciplines of pharmacy, materials science, and biomedicine continue to advance and converge, the development of efficient and safe drug delivery systems, including biopharmaceutical formulations, has garnered significant attention both domestically and internationally. This article presents an overview of the latest advancements in drug delivery systems, categorized into four primary areas: carrier-based and coupling-based targeted drug delivery systems, intelligent drug delivery systems, and drug delivery devices, based on their main objectives and methodologies. Additionally, it critically analyzes the technological bottlenecks, current research challenges, and future trends in the application of novel drug delivery systems.

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Section: Stimulation Responsivementioning

confidence: 99%