The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation

Gazivoda, Tatjana; Plevnik, Miha; Plavec, Janez; Kraljević, Sandra; Kralj, Marijeta; Pavelić, Krešimir; Balzarini, Jan; Clercq, Erik De; Mintas, Mladen; Raić‐Malić, Silvana

doi:10.1016/j.bmc.2004.09.052

Cited by 37 publications

(24 citation statements)

References 25 publications

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“…Cell viability was quantitatively determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. Experimentally obtained absorbance values were transformed into a cell percentage growth (PG) using the formulas proposed by NIH and described previously [34]. The IC 50 and LC 50 values for each compound were calculated from concentrationeresponse curves using linear regression analysis by fitting the test concentrations that give PG values above and below the reference value.…”

Section: Antiproliferative Evaluationmentioning

confidence: 99%

Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

Hranjec

Starčević

Pavelić

et al. 2011

European Journal of Medicinal Chemistry

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124

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Section: Antiproliferative Evaluationmentioning

confidence: 99%

Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

Hranjec

Starčević

Pavelić

et al. 2011

European Journal of Medicinal Chemistry

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124

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“…After 48 (L1210) or 72 h (CEM, Molt4/C8), the tumour-cell number was determined by a Coulter counter. For the anti-proliferative assays, a panel of monolayer tumour cell lines (hepatocellularcarcinoma Hep G2, cervical carcinoma HeLa, breast carcinoma MCF-7, pancreatic carcinoma MiaPaCa-2, colon carcinoma SW 620 and human normal fibroblasts (WI 38) was used for a standard MTT assay as described previously (Gazivoda et al, 2005).…”

Section: Proliferation Assaysmentioning

confidence: 99%

“…The IC 50 and LC 50 values for each compound were calculated from dose-response curves using linear regression analysis as described previously (Gazivoda et al, 2005).…”

Section: Proliferation Assaysmentioning

confidence: 99%

Synthesis, cytostatic and anti-viral activity evaluation of the novel acyclic nucleoside analogues containing a sterically constrained (Z)-4-amino-2-butenyl moiety

Wittine

Pavelić

et al. 2010

Med Chem Res

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A series of the novel pyrimidine (3-6) and purine (12)(13)(14)(15)(18)(19)(20)(21) acyclic nucleoside analogues in which the sugar moiety was replaced by a sterically constrained Z-4-amino-, 4-aminohydrochloride-2-butenyl, or aliphatic 4-aminohydrochloride-2-butyl moiety were synthesized and evaluated for their anti-viral and cytostatic activity potency. Cytostatic evaluation of the novel compounds on selected panel of human tumour-cell lines showed that the majority of compounds exerted a nonspecific anti-proliferative effect at the highest tested concentration (i.e. 1 9 10 -4 M) against all cell lines. Nevertheless, a rather moderate but selective anti-proliferative effects on HeLa cell cultures in comparison to normal fibroblasts WI 38, were observed for compounds 15 and 21. No anti-viral activity was observed, except for compounds 3, 4, 5 and 19 that showed anti-HIV activity at 50% effective concentration ranging between 10 and 96 lM.

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“…Pyrimidine derivatives are versatile building blocks in synthetic organic chemistry and many bioactive molecules [1][2][3][4] with pyrimidine skeleton served as M1 muscarinic receptor agonists for the treatment of Alzheimer's disease [5,6] and human immune deficiency virus (HIV) protease inhibitors [7]. Pyrimidine moiety is an important class of N-containing heterocyclic system [8,9], which exhibits wide spectrum of biological activities such as bactericidal [10], fungicidal [11], analgesic [12], anti-hypertensive [13], antimicrobial [14] and anti-infective properties [15].…”

Section: Introductionmentioning

confidence: 99%

Aqueous phase synthesis of polysubstituted pyrimidines/pyrrolidines catalyzed by β-cyclodextrin

et al. 2014

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KEYWORDSHighly substituted pyrimidine/pyrrolidine derivatives were synthesized for the first time in water under neutral conditions by the reaction of aromatic amines, dimethyl/diethyl acetylene dicarboxylates, formaldehyde mediated by β-cyclodextrin (β-CD) in good to excellent yields. β-Cyclodextrin can be recovered and reused without any loss of catalytic activity. The β-Cyclodextrins employed were inexpensive and readily available when compared to other types of cyclodextrins (α, γ).Amines Formaldehyde β-Cyclodextrin Pyrimidine derivatives Pyrrolidine derivatives Dimethyl/diethyl acetylene dicarboxylates

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The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation

Cited by 37 publications

References 25 publications

Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

Synthesis, cytostatic and anti-viral activity evaluation of the novel acyclic nucleoside analogues containing a sterically constrained (Z)-4-amino-2-butenyl moiety

Aqueous phase synthesis of polysubstituted pyrimidines/pyrrolidines catalyzed by β-cyclodextrin

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